Chotosan

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chotosan

Chinese: Gou Teng San

English: Uncaria Decoction

Source: Pujibenshifang (Moxibustion in Prescriptions for Universal Relief)

Pulse: bowstring, rapid

Tongue: red,body, greasy fur

Abdomen: shinkahiko

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

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There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

Herbs in This Formula

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Basic and Clinical Research on Chotosan – Updated on June 16, 2012

Zhao Q, Yokozawa T, Tsuneyama K, Tanaka K, Miyata T, Shibahara N, et al. Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic/neurotrophic factors and neuroplasticity systems in the brain. Chinese medicine. 2011;6:33.

Zhao Q, Murakami Y, Tohda M, Obi R, Shimada Y, Matsumoto K. Chotosan, a kampo formula, ameliorates chronic cerebral hypoperfusion-induced deficits in object recognition behaviors and central cholinergic systems in mice. Journal of pharmacological sciences. 2007;103(4):360-73.

Obi R, Tohda M, Zhao Q, Obi N, Hori H, Murakami Y, et al. Chotosan enhances macrophage colony-stimulating factor mRNA expression in the ischemic rat brain and C6Bu-1 glioma cells. Biological & pharmaceutical bulletin. 2007;30(12):2250-6.

Terasawa K. Chotosan in the treatment of vascular dementia. Pharma Medica 2007; 25: 57-9 (in Japanese).

Suzuki T, Futami S, Igari Y, Matsumura N, Watanabe K, Nakano H, et al. A Chinese herbal medicine, choto-san, improves cognitive function and activities of daily living of patients with dementia: a double-blind, randomized, placebo-controlled study. Journal of the American Geriatrics Society. 2005;53(12):2238-40.

Zhao Q, Murakami Y, Tohda M, Watanabe H, Matsumoto K. Preventive effect of chotosan, a Kampo medicine, on transient ischemia-induced learning deficit is mediated by stimulation of muscarinic M1 but not nicotinic receptor. Biological & pharmaceutical bulletin. 2005;28(10):1873-8.

Murakami Y, Zhao Q, Harada K, Tohda M, Watanabe H, Matsumoto K. Choto-san, a Kampo formula, improves chronic cerebral hypoperfusion-induced spatial learning deficit via stimulation of muscarinic M1 receptor. Pharmacology, biochemistry, and behavior. 2005;81(3):616-25.

Hayashi H, Tohda M, Watanabe H, Murakami Y, Matsumoto K. The effects of Choto-san on the mRNA expression of Alzheimer’s disease related factors in the permanent ischemic rat brain. Biological & pharmaceutical bulletin. 2005;28(4):744-6.

Mahakunakorn P, Tohda M, Murakami Y, Watanabe H, Matsumoto K. Effects of Choto-san and its related constituents on endogenous antioxidant systems. Biological & pharmaceutical bulletin. 2005;28(1):53-7.

Yokoyama K, Shimada Y, Hori E, Nakagawa T, Takagi S, Sekiya N, et al. Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia. Journal of ethnopharmacology. 2004;95(2-3):335-43.

Yokoyama K, Shimada Y, Hori E, Sekiya N, Goto H, Sakakibara I, et al. Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2004;11(6):478-89.

Dohi K, Aruga T, Satoh K, Shioda S. Choto-san (kampo Medicine) for the treatment of headache. Headache. 2004;44(4):375.

Dohi K, Satoh K, Ikeda Y, Ohtaki H, Shioda S, Aruga T. Neuroprotective effect from ischemia and direct free radical scavenging activity of Choto-san (kampo medicine). Acta neurochirurgica Supplement. 2003;86:123-7.

Mahakunakorn P, Tohda M, Murakami Y, Matsumoto K, Watanabe H. Antioxidant and free radical-scavenging activity of Choto-san and its related constituents. Biological & pharmaceutical bulletin. 2004;27(1):38-46.

Yamaguchi S, Matsubara M, Kobayashi S. Event-related brain potential changes after Choto-san administration in stroke patients with mild cognitive impairments. Psychopharmacology. 2004;171(3):241-9.

Watanabe H, Zhao Q, Matsumoto K, Tohda M, Murakami Y, Zhang SH, et al. Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine. Pharmacology, biochemistry, and behavior. 2003;75(3):635-43.

Mizushima Y, Kan S, Yoshida S, Irie Y, Urata Y. Effect of Choto-san, a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse (SAM). Phytotherapy research : PTR. 2003;17(5):542-5.

Shimada Y, Yang Q, Yokoyama K, Goto H, Kasahara Y, Sekiya N, et al. Choto-san prevents occurrence of stroke and prolongs life span in stroke-prone spontaneously hypertensive rats. The American journal of Chinese medicine. 2003;31(1):79-85.

Sekiya N, Shimada Y, Shibahara N, Takagi S, Yokoyama K, Kasahara Y, et al. Inhibitory effects of Choto-san (Diao-teng-san), and hooks and stems of Uncaria sinensis on free radical-induced lysis of rat red blood cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2002;9(7):636-40. Epub 2002/12/19.

Yang Q, Goto H, Shimada Y, Kita T, Shibahara N, Terasawa K. Effects of Choto-san on hemorheological factors and vascular function in stroke-prone spontaneously hypertensive rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2002;9(2):93-8.

Goto H, Yang Q, Kita T, Hikiami H, Shimada Y, Terasawa K. Effects of Choto-san on microcirculation, serum nitric oxide and lipid peroxides in patients with asymptomatic cerebral infarction. The American journal of Chinese medicine. 2001;29(1):83-9

Sugimoto A, Goto K, Ishige A, Komatsu Y, Miyamoto KI. Effect of Choto-san, a Kampo medicine, on the cerebral blood flow autoregulation in spontaneously hypertensive rats. Japanese journal of pharmacology. 2000;83(2):135-42.

Itoh T, Shimada Y, Terasawa K. Efficacy of Choto-san on vascular dementia and the protective effect of the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death. Mechanisms of ageing and development. 1999;111(2-3):155-73.

Yuzurihara M, Goto K, Sugimoto A, Ishige A, Komatsu Y, Shimada Y, et al. Effect of Choto-san, a kampo medicine, on impairment of passive avoidance performance in mice. Phytotherapy research : PTR. 1999;13(3):233-5

Mimaki Y, Toshimizu N, Yamada K, Sashida Y. [Anti-convulsion effects of choto-san and chotoko (Uncariae Uncis cam Ramlus) in mice, and identification of the active principles]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1997;117(12):1011-21.

Nishizawa Y, Nishizawa Y, Fushiki S. Analgesic effects on headache in patients with spinal cord injury. Nippon Zutsu Gakkaishi (Japanese Journal of Headache) 1997; 25: 23-6.

Terasawa K, Shimada Y, Kita T, et al. Choto-san in the treatment of vascular dementia: A double blind, placebo-controlled study. Phytomedicine 1997; 4: 15-22.

Narumi J, Kohsaka S, Miyazawa S, et al. Evaluation of the Kampo monotreatment for hypertensive patients using ambulatory blood pressure monitoring. Kampo Shinryo 1996; 15: 34-5 (in Japanese).

Matsushita S, Ueda S, Ouchi Y, et al. Usefulness of chotosan (TJ-47) for relieving the accompanying symptoms and sequelae of cerebrovascular disease, chronic cerebrovascular insufficiency, or hypertension. Geriatric Medicine 1995; 33: 1333-41 (in Japanese).

Shimada Y, Terasawa K, Yamamoto T, et al. A well-controlled study of Choto-san and placebo in the treatment of vascular dementia. Wakan Iyakugaku Zasshi (Journal of Traditional Medicines) 1994; 11: 246-55.

Shimada Y, Terasawa K, Yamamoto T, et al. Efficacy of Choto-san on vascular dementia: A well, placebo-controlled study. Wakan Iyakugaku Zasshi (Journal of Traditional Medicines) 1994; 11: 370-1 (in Japanese).

Narumi J, Kohsaka S, Miyazawa S, et al. Evaluation of the Kampo monotreatment for hypertensive patients using ambulatory blood pressure monitor. Wakan Iyakugaku Zasshi (Journal of Traditional Medicines) 1994; 11: 282-3 (in Japanese).

Sasaki J, Matsunaga A, Kusuda M, et al. Efficacy of daisaikoto and chotosan in patients with essential hypertension.  Rinsho to Kenkyu (Japanese Journal of Clinical and Experimental Medicine) 1993; 70: 1965-75 (in Japanese).