Chinese: Da Jian Zhong Tang
English: Major Construct the Middle Decoction
Source: Jinguiyaolue (Essentials from the Golden Cabinet)
Pulse: sunken, bowstring or slow
Tongue: pale or purple body, white slippery fur
Abdomen: weak to medium abdominal wall strength, zendofuon
Indications: This herbal formula has been used for patients with following health conditions and symptoms:
member section
Basic and Clinical Research on Daikenchuto – Updated on June 16, 2012
Yoshikawa K, Shimada M, Nishioka M, Kurita N, Iwata T, Morimoto S, et al. The effects of the Kampo medicine (Japanese herbal medicine) “Daikenchuto” on the surgical inflammatory response following laparoscopic colorectal resection. Surgery today. 2012;42(7):646-51.
Iwasa T, Ogino H, Nakamura K, Ihara E, Akiho H, Takayanagi R. Feeding Administration of Daikenchuto Suppresses Colitis Induced by Naive CD4(+) T Cell Transfer into SCID Mice. Digestive diseases and sciences. 2012.
Chikakiyo M, Shimada M, Nakao T, Higashijima J, Yoshikawa K, Nishioka M, et al. Kampo medicine “Dai-kenchu-to” prevents CPT-11-induced small-intestinal injury in rats. Surgery today. 2012;42(1):60-7. Epub 2011/11/10.
Yasunaga H, Miyata H, Horiguchi H, Kuwabara K, Hashimoto H, Matsuda S. Effect of the Japanese herbal kampo medicine dai-kenchu-to on postoperative adhesive small bowel obstruction requiring long-tube decompression: a propensity score analysis. Evidence-based complementary and alternative medicine : eCAM. 2011;2011:264289.
Tokita Y, Yamamoto M, Satoh K, Nishiyama M, Iizuka S, Imamura S, et al. Possible involvement of the transient receptor potential vanilloid type 1 channel in postoperative adhesive obstruction and its prevention by a kampo (traditional Japanese) medicine, daikenchuto. Journal of pharmacological sciences. 2011;115(1):75-83.
Munekage M, Kitagawa H, Ichikawa K, Watanabe J, Aoki K, Kono T, et al. Pharmacokinetics of daikenchuto, a traditional Japanese medicine (kampo) after single oral administration to healthy Japanese volunteers. Drug metabolism and disposition: the biological fate of chemicals. 2011;39(10):1784-8.
Kono T, Omiya Y, Hira Y, Kaneko A, Chiba S, Suzuki T, et al. Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn’s disease rat model. Journal of gastroenterology. 2011;46(10):1187-96.
Kono T. [Kampo medicine daikenchuto–Its Exodus from the complementary and alternative medicines]. Nihon yakurigaku zasshi Folia pharmacologica Japonica. 2011;137(1):13-7.
Inoue K, Naito Y, Takagi T, Hayashi N, Hirai Y, Mizushima K, et al. Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model. Biological & pharmaceutical bulletin. 2011;34(11):1659-65.
Akiho H, Nakamura K. Daikenchuto ameliorates muscle hypercontractility in a murine T-cell-mediated persistent gut motor dysfunction model. Digestion. 2011;83(3):173-9.
Wood MJ, Hyman NH, Mawe GM. The effects of daikenchuto (DKT) on propulsive motility in the colon. The Journal of surgical research. 2010;164(1):84-90.
Takagi A, Yagi M, Tanaka Y, Asagiri K, Asakawa T, Tanaka H, et al. The herbal medicine daikenchuto ameliorates an impaired anorectal motor activity in postoperative pediatric patients with an anorectal malformation–a pilot study. International surgery. 2010;95(4):350-5.
Manabe N, Camilleri M, Rao A, Wong BS, Burton D, Busciglio I, et al. Effect of daikenchuto (TU-100) on gastrointestinal and colonic transit in humans. American journal of physiology Gastrointestinal and liver physiology. 2010;298(6):G970-5.
Kono T, Kaneko A, Hira Y, Suzuki T, Chisato N, Ohtake N, et al. Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn’s disease mouse model. Journal of Crohn’s & colitis. 2010;4(2):161-70.
Iwabu J, Watanabe J, Hirakura K, Ozaki Y, Hanazaki K. Profiling of the compounds absorbed in human plasma and urine after oral administration of a traditional Japanese (kampo) medicine, daikenchuto. Drug metabolism and disposition: the biological fate of chemicals. 2010;38(11):2040-8.
Takayama S, Seki T, Watanabe M, Monma Y, Sugita N, Konno S, et al. The herbal medicine Daikenchuto increases blood flow in the superior mesenteric artery. The Tohoku journal of experimental medicine. 2009;219(4):319-30.
Narita M, Hatano E, Tamaki N, Yamanaka K, Yanagida A, Nagata H, et al. Dai-kenchu-to attenuates rat sinusoidal obstruction syndrome by inhibiting the accumulation of neutrophils in the liver. Journal of gastroenterology and hepatology. 2009;24(6):1051-7.
Kawasaki N, Nakada K, Suzuki Y, Furukawa Y, Hanyu N, Kashiwagi H. Effect of Dai-kenchu-to on gastrointestinal motility and gastric emptying. International journal of surgery. 2009;7(3):218-22.
Kawahara H, Yanaga K. The herbal medicine Dai-Kenchu-To directly stimulates colonic motility. Surgery today. 2009;39(2):175-7.
Hirakawa H, Ueno S, Matuda H, Hinoki T, Kato Y. Effect of the herbal medicine dai-kenchu-to on gastrointestinal motility in patients with megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) and chronic idiopathic intestinal pseudo-obstruction (CIIP): report of two cases. The Tokai journal of experimental and clinical medicine. 2009;34(1):28-33.
Yoshikawa K, Kurita N, Higashijima J, Miyatani T, Miyamoto H, Nishioka M, et al. Kampo medicine “Dai-kenchu-to” prevents bacterial translocation in rats. Digestive diseases and sciences. 2008;53(7):1824-31.
Takeda T, Kamiura S, Kimura T. Effectiveness of the herbal medicine daikenchuto for radiation-induced enteritis. Journal of alternative and complementary medicine. 2008;14(6):753-5.
Ogasawara T, Morine Y, Ikemoto T, Imura S, Fujii M, Soejima Y, et al. Influence of Dai-kenchu-to (DKT) on human portal blood flow. Hepato-gastroenterology. 2008;55(82-83):574-7.
Kono T, Koseki T, Chiba S, Ebisawa Y, Chisato N, Iwamoto J, et al. Colonic vascular conductance increased by Daikenchuto via calcitonin gene-related peptide and receptor-activity modifying protein 1. The Journal of surgical research. 2008;150(1):78-84.
Tokita Y, Yuzurihara M, Sakaguchi M, Satoh K, Kase Y. The pharmacological effects of Daikenchuto, a traditional herbal medicine, on delayed gastrointestinal transit in rat postoperative ileus. Journal of pharmacological sciences. 2007;104(4):303-10.
Tokita Y, Satoh K, Sakaguchi M, Endoh Y, Mori I, Yuzurihara M, et al. The preventive effect of Daikenchuto on postoperative adhesion-induced intestinal obstruction in rats. Inflammopharmacology. 2007;15(2):65-6.
Kawasaki N, Nakada K, Nakayoshi T, Furukawa Y, Suzuki Y, Hanyu N, et al. Effect of Dai-kenchu-to on gastrointestinal motility based on differences in the site and timing of administration. Digestive diseases and sciences. 2007;52(10):2684-94.
Iwai N, Kume Y, Kimura O, Ono S, Aoi S, Tsuda T. Effects of herbal medicine Dai-Kenchu-to on anorectal function in children with severe constipation. European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery [et al] = Zeitschrift fur Kinderchirurgie. 2007;17(2):115-8.
Takagi K, Nagata H, Horie T, et al. Effect of the preventive herbal therapy using Dai-kenchu-to on intestinal obstruction following curative resection for colorectal cancer: prospective, randomized study. Kampo Kenkyu (Kampo Research) 2007; (429): 270-1 (in Japanese).
Endo S, Nishida T, Nishikawa K, et al. Dai-kenchu-to, a Chinese herbal medicine, improves stasis of patients with total gastrectomy and jejunal pouch interposition. American Journal of Surgery 2006; 192: 9-13.
Sato Y, Inoue S, Katagiri F, Itoh H, Takeyama M. Effects of pirenzepine on Dai-kenchu-to-induced elevation of the plasma neuropeptide levels in humans. Biological & pharmaceutical bulletin. 2006;29(1):166-71.
Kito Y, Suzuki H. Effects of Dai-kenchu-to on spontaneous activity in the mouse small intestine. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2006;42(6):189-201.
Fukuda H, Chen C, Mantyh C, Ludwig K, Pappas TN, Takahashi T. The herbal medicine, Dai-Kenchu-to, accelerates delayed gastrointestinal transit after the operation in rats. The Journal of surgical research. 2006;131(2):290-5.
Endo S, Nishida T, Nishikawa K, Nakajima K, Hasegawa J, Kitagawa T, et al. Dai-kenchu-to, a Chinese herbal medicine, improves stasis of patients with total gastrectomy and jejunal pouch interposition. American journal of surgery. 2006;192(1):9-13.
Suehiro T, Matsumata T, Shikada Y, Sugimachi K. The effect of the herbal medicines dai-kenchu-to and keishi-bukuryo-gan on bowel movement after colorectal surgery. Hepato-gastroenterology. 2005;52(61):97-100.
Sakakibara R, Odaka T, Lui Z, Uchiyama T, Yamaguchi K, Yamaguchi T, et al. Dietary herb extract dai-kenchu-to ameliorates constipation in parkinsonian patients (Parkinson’s disease and multiple system atrophy). Movement disorders : official journal of the Movement Disorder Society. 2005;20(2):261-2.
Kaiho T, Tanaka T, Tsuchiya S, Yanagisawa S, Takeuchi O, Miura M, et al. Effect of the herbal medicine Dai-kenchu-to for serum ammonia in hepatectomized patients. Hepato-gastroenterology. 2005;52(61):161-5.
Saida Y, Sumiyama Y, Nagao J, et al. Dai-kenchu-to, a herbal medicine, improves precolonoscopy bowel preparation with polyethylene glycol electrolyte lavage: results of a prospective randomized controlled trial. Digestive Endoscopy 2005; 17: 50-3.
Saida Y, Nagao J, Nakamura Y, et al. Dai-kenchu-to and mosapride in combination with precolonoscopy bowel preparation with polyethylene glycol electrolyte lavage: results of a prospective randomized controlled trial. Nihon Daicho Kensa Gakkai Zasshi (Journal of the Japan Society of Colon Examination) 2005; 22: 145-8 (in Japanese).
Sato Y, Katagiri F, Inoue S, Itoh H, Takeyama M. Dai-kenchu-to raises levels of calcitonin gene-related peptide and substance P in human plasma. Biological & pharmaceutical bulletin. 2004;27(11):1875-7.
Satoh K, Kase Y, Yuzurihara M, Mizoguchi K, Kurauchi K, Ishige A. Effect of Dai-kenchu-to (Da-Jian-Zhong-Tang) on the delayed intestinal propulsion induced by chlorpromazine in mice. Journal of ethnopharmacology. 2003;86(1):37-44.
Ohya T, Usui Y, Arii S, Iwai T, Susumu T. Effect of dai-kenchu-to on obstructive bowel disease in children. The American journal of Chinese medicine. 2003;31(1):129-35.
Nakamura T, Sakai A, Isogami I, Noda K, Ueno K, Yano S. Abatement of morphine-induced slowing in gastrointestinal transit by Dai-kenchu-to, a traditional Japanese herbal medicine. Japanese journal of pharmacology. 2002;88(2):217-21.
Murata P, Kase Y, Ishige A, Sasaki H, Kurosawa S, Nakamura T. The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats. Life sciences. 2002;70(17):2061-70. Epub 2002/08/01.
Itoh T, Yamakawa J, Mai M, Yamaguchi N, Kanda T. The effect of the herbal medicine dai-kenchu-to on post-operative ileus. The Journal of international medical research. 2002;30(4):428-32. Epub 2002/09/19.
Arai J, Nakajima S, Fujinuma S, et al. A Comparative study of bowel preparation for barium enema using divided administrations of powdered magnesium citrate with mosapride or DAIKEN CHUTOU. Nihon Daicho Kensa Gakkai Zasshi (Journal of the Japan Society of Colon Examination) 2002; 19: 170-3 (in Japanese).
Itoh T, Yamakawa J, Mai M, et al. The effect of the herbal medicine Dai-kenchu-to on post-operative ileus. The Journal of International Medical Research 2002; 30: 428-32.
Tulimat MA, Ishiguchi T, Kurosawa S, Nakamura T, Takahashi T. The inhibitory effect of herbal medicine -Dai Kenchu To (DKT)- on the colonic motility in rats in vitro. The American journal of Chinese medicine. 2001;29(1):111-8.
Satoh K, Kase Y, Hayakawa T, Murata P, Ishige A, Sasaki H. Dai-kenchu-to enhances accelerated small intestinal movement. Biological & pharmaceutical bulletin. 2001;24(10):1122-6.
Satoh K, Hayakawa T, Kase Y, Ishige A, Sasaki H, Nishikawa S, et al. Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum. Digestive diseases and sciences. 2001;46(2):250-6.
Satoh K, Hashimoto K, Hayakawa T, Ishige A, Kaneko M, Ogihara S, et al. Mechanism of atropine-resistant contraction induced by Dai-kenchu-to in guinea pig ileum. Japanese journal of pharmacology. 2001;86(1):32-7.
Murata P, Hayakawa T, Satoh K, Kase Y, Ishige A, Sasaki H. Effects of Dai-kenchu-to, a herbal medicine, on uterine and intestinal motility. Phytotherapy research : PTR. 2001;15(4):302-6. Epub 2001/06/15.
Takagaki Y, Kawasaki S, Komai H, et al. The effect of Chinese hearb medicine (dai-kenchu-to) on paralytic ileus after repair of abdominal aortic aneurysm. Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 2000; 61: 325-8
Nagano T, Itoh H, Takeyama M. Effects of Dai-kenchu-to on levels of 5-hydroxytryptamine (serotonin) and vasoactive intestinal peptides in human plasma. Biological & pharmaceutical bulletin. 2000;23(3):352-3.
Nagano T, Itoh H, Takeyama M. Effect of Dai-kenchu-to on levels of 3 brain-gut peptides (motilin, gastrin and somatostatin) in human plasma. Biological & pharmaceutical bulletin. 1999;22(10):1131-3.
Hayakawa T, Kase Y, Saito K, Hashimoto K, Ishige A, Komatsu Y, et al. Effects of Dai-kenchu-to on intestinal obstruction following laparotomy. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 1999;35(2):47-54.
Hayakawa T, Kase Y, Saito K, Hashimoto K, Ishige A, Komatsu Y, et al. Pharmacological studies of the effect of Dai-kenchu-to on spontaneous contraction of isolated rabbit jejunum. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 1999;35(2):55-62.
Nagashima Y, Tanaka N, Furukawa K, et al. Effects of daikenchuto (TJ-100) on intestinal paralysis after surgery for colorectal cancer. Progress in Medicine 1998; 18: 903-5 (in Japanese).
Ohyabu H, Matsuda S, Kurisu S, et al. Evaluation of daikenchuto in patients with adhesive ileus in a randomized trial. Progress in Medicine 1995; 15: 1954-8 (in Japanese)
Kubo N, Uchida Y, Akiyoshi T, et al. Efficacy of daikenchuto for ileus – a multicenter study. Progress in Medicine 1995; 15: 1962-7 (in Japanese).
Adachi I. Supporting therapy with Shi Quan Da Bu Tang in advanced breast cancer patients. Biomedical Research 1990; 11 suppl: 25-31.
Adachi I, Watanabe T, Chen JY, et al. Supportive therapy of oriental medicine for patients with advanced breast cancer. Gan to Kagaku Ryoho (Japanese Journal of Cancer and Chemotherapy) 1989; 16: 1538-43
Adachi I. Juzen-taiho-to as a supporting therapy in advanced breast cancer. Biotherapy 1989; 3: 782-8