Chinese: Jia Wei Xiao Yao San (Dan Zhi Xiao Yao San)

English: Augmented Rambling Powder

Source: Nei ke zhai yao (Summary of Internal Medicine)

Pulse: bowstring, fine, rapid

Tongue: red body, yellow fur

Abdomen: Weak abdominal wall, mild kyokyokuman

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Irritability
  • Restlessness
  • Palpitation
  • Dizziness
  • Headaches
  • Anxiety
  • Insomnia
  • Spontaneous sweating
  • Fatigue
  • Heat sensation in head
  • Red eyes
  • Dry mouth
  • Irregular menstruation
  • Abdominal cramps
  • Infertility

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.


Herbs in This Formula


Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.

Basic and Clinical Research on Kamishoyosan (Jia Wei Xiao Yao San) – Updated on Mar 30, 2011

Terauchi, M., et al. Effects of three Kampo formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) on Japanese peri- and postmenopausal women with sleep disturbances. Archives of gynecology and obstetrics (2010).

Qu, Y., Gan, H.Q., Mei, Q.B. & Liu, L. Study on the effect of Jia-Wei-Xiao-Yao-San decoction on patients with functional dyspepsia. Phytother Res 24, 245-248 (2010).

Higuchi T, Tarakida A, Abe K, et al. Comparing the effects of hormone replacement therapy and kamishoyosan treatment on climacteric disorders*. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 26: 18-23 (2009)

Yasui T, Yamada M, Uemura H, et al. Changes in circulating cytokine levels in midlife women with psychological symptoms with selective serotonin reuptake inhibitor and Japanese traditional medicine. Maturitas 62: 146-52 (2009).

Zhang, H., et al. Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection. Journal of pharmaceutical and biomedical analysis 48, 1462-1466 (2008).

Yamada, K. & Kanba, S. Effectiveness of kamishoyosan for premenstrual dysphoric disorder: open-labeled pilot study. Psychiatry and clinical neurosciences 61, 323-325 (2007).

Lee, J.G., Shin, B.S., Lee, Y.C., Park, S.W. & Kim, Y.H. Clinical effectiveness of the Kampo medicine kamishoyosan for adjunctive treatment of tardive dyskinesia in patients with schizophrenia: a 16-week open trial. Psychiatry and clinical neurosciences 61, 509-514 (2007).

Kimura, Y., et al. Kampo therapy for premenstrual syndrome: efficacy of Kamishoyosan quantified using the second derivative of the fingertip photoplethysmogram. The journal of obstetrics and gynaecology research 33, 325-332 (2007).

Takamatsu K. Study of the usefulness of Kampo therapy for climacteric disorders – a randomized trial of three major Kampo medicines for treatment of gynecological disease. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 23: 35-42 (2006).

Toriizuka, K., et al. Anxiolytic effect of Gardeniae Fructus-extract containing active ingredient from Kamishoyosan (KSS), a Japanese traditional Kampo medicine. Life sciences 77, 3010-3020 (2005).

Ushiroyama T, Ikeda A, Sakuma K, et al. Changes in serum tumor necrosis factor (TNF-alpha) with kami-shoyo-san administration in depressed climacteric patients. American Journal of Chinese Medicine 32: 621-9 (2004).

Takamatsu K, Musha C, Okano H, et al. Study of usefulness of Kampo therapy for climacteric disorders. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 19: 111-6 (2002).

Ota H. Positioning of Kampo therapy and hormone replacement therapy in treatment of climacteric disorders. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 18: 21-9 (2001).

Inoue M. Kampo treatment for mastitis – kamishoyosan -*. Kampo Igaku (Kampo Medicine) 18: 238-41 (1994).

Kano T, Ito C, Kasamatsu H, et al. Clinical study of prognosis of 200 deliveries after kampo-treatment for ovarian dysfunctional infertilities and tocolysis. Nihon Funin Gakkai Zasshi (Japanese Journal of Fertility and Sterility) 36: 612-20 (1991).