Chinese: Gui Zhi Fu Ling Wan

English: Cinnamon Twig and Poria Pill

Source: Jinguiyaolue (Essentials from the Golden Cabinet)

Pulse: choppy

Tongue: purple body, stasis spots

Abdomen: oketsuten, shofukuman

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Localized abdominal pain
  • Abnormal uterine bleeding
  • Heavy menstrual flow
  • Dark clots with menstrual blood
  • Amenorrhea
  • Dysmenorrhea
  • Infertility
  • Dizziness
  • Headaches
  • Neck and shoulder stiffness
  • Contusion
  • Bruising
  • Heat sensation in head
  • Cold feet
  • Red eyes

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

Herbs in This Formula


Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.

Basic and Clinical Research on Keishibukuryogan (Gui Zhi Fu Ling Wan) – Updated on Mar 30, 2011

Terauchi, M., et al. Effects of three Kampo formulae: Tokishakuyakusan (TJ-23), Kamishoyosan (TJ-24), and Keishibukuryogan (TJ-25) on Japanese peri- and postmenopausal women with sleep disturbances. Archives of gynecology and obstetrics (2010).

Fujita, K., Yamamoto, T., Kamezaki, T. & Matsumura, A. Efficacy of keishibukuryogan, a traditional Japanese herbal medicine, in treating cold sensation and numbness after stroke: clinical improvement and skin temperature normalization in 22 stroke patients. Neurologia medico-chirurgica 50, 1-5; discussion 5-6 (2010).

Fujimoto, M., et al. The traditional Japanese formula keishibukuryogan reduces liver injury and inflammation in patients with nonalcoholic fatty liver disease. Annals of the New York Academy of Sciences 1190, 151-158 (2010).

Uchida N. A Randomized controlled trial of the Chinese herbal medicine Keisi-bukuryo-gan (Gui-Zhi-Fu-Ling-Wan) in the treatment of deep vein thrombosis. Jomyakugaku (The Japanese Journal of Phlebology) 20:1-6 (2009).

Nakagawa, T., et al. Keishibukuryogan Reduces Renal Injury in the Early Stage of Renal Failure in the Remnant Kidney Model. Evid Based Complement Alternat Med (2009).

Nakagawa, T., et al. Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Diabetes research and clinical practice 80, 40-47 (2008).

Ogawa, K., et al. Identification of a predictive biomarker for the beneficial effect of a Kampo (Japanese traditional) medicine keishibukuryogan in rheumatoid arthritis patients. Clinical biochemistry 40, 1113-1121 (2007).

Nozaki, K., et al. Effects of keishibukuryogan on vascular function in adjuvant-induced arthritis rats. Biological & pharmaceutical bulletin 30, 1042-1047 (2007).

Nakagawa, T., et al. Protective effects of keishibukuryogan on the kidney of spontaneously diabetic WBN/Kob rats. Journal of ethnopharmacology 110, 311-317 (2007).

Nozaki, K., et al. Keishibukuryogan (gui-zhi-fu-ling-wan), a kampo formula, decreases disease activity and soluble vascular adhesion molecule-1 in patients with rheumatoid arthritis. Evid Based Complement Alternat Med 3, 359-364 (2006).

Ushiroyama T, Hosotani T, Mori K, et al. Effects of switching to wen-jing-tang (unkei-to) from preceding herbal preparations selected by eight-principle pattern identification on endocrinological status and ovulatory induction in women with polycystic ovary syndrome. The American Journal of Chinese Medicine 34: 177-87 (2006)

Takamatsu K. Study of the usefulness of Kampo therapy for climacteric disorders – a randomized trial of three major Kampo medicines for treatment of gynecological disease–*. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 23: 35-42 (2006).

Ushiroyama, T., Ikeda, A., Sakuma, K. & Ueki, M. Comparing the effects of estrogen and an herbal medicine on peripheral blood flow in post-menopausal women with hot flashes: hormone replacement therapy and gui-zhi-fu-ling-wan, a Kampo medicine. The American journal of Chinese medicine 33, 259-267 (2005).

Suehiro T, Matsumata T, Shikada Y,et al. The effect of the herbal medicines Dai-kenchu-to and Keishi-bukuryo-gan on bowel movement after colorectal surgery. Hepato-Gastroenterology 52: 97-100 (2005).

Sato N, Takei N, Ikejima K, et al. Effects of a combination preparation of Guizhi Fuling Wan and vitamin E on indefinite complaints such as stiffness of shoulder and cold feeling. Toho Igaku (Eastern Medicine) 19; 23-43 (2004)

Takamatsu K. HRT and Kampo medicine*. Nippon Konenki Igakkai Zasshi (The Journal of the Japan Menopause Society) 12:155-7 (2004).

Hikiami H, Goto H, Sekiya N, et al. Comparative efficacy of Keishi-bukuryo-gan and pentoxifylline on RBC deformability in patients with “oketsu” syndrome. Phytomedicine 10: 459-66 (2003).

Yamamoto K, Hirano F, Ikoma N, et al. Efficacy of keishibukuryogan for hysteromyoma/uterine adenomyosis. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 20: 135-7 (2003).

Ogita Y, Fujimoto S, Ushiroyama T, et al. Keishibukuryogan formulation TK-061 prepared with crude drug – verification of efficacy for various climacteric symptoms*. Sanka to Fujinka (Obstetrics and Gynecology) 69: 953-62 (2002).

Takamatsu K, Musha C, Okano H, et al. Study of usefulness of Kampo therapy for climacteric disorders. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 19: 111-6 (2002).

Ogita Y, Fujimoto S, Ushiroyama T, et al. Efficacy of formulation TK-061 for various climacteric symptoms – comparison with Teikoku Keishibukuryogan Extract Granules. Rinsho Fujinka Sanka (Clinical Gynecology and Obstetrics) 56: 799-810 (2002).

Ota H. Positioning of Kampo therapy and hormone replacement therapy in treatment of climacteric disorders*. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 18: 21-9 (2001).

Sakamoto S, Mitamura T, Iwasawa M, et al. Conservative management for perimenopausal women with uterine leiomyomas using Chinese herbal medicines and synthetic analogs of gonadotropin-releasing hormone. In Vivo 12: 333-8 (1998).

Tanaka E, Saito H, Hiroi M. Kampo treatment for nonspecific complaints in climacteric women – comparison of clinical efficacy of Kampo medicine alone versus Kampo medicine combined with tofisopam. Kampo Shinryo 16: 22-4 (1997).

Ohta H, Makita K. Lumbago – with emphasis on nonspecific lumbago, which obstetricians and gynecologists think is the most common form in women . Chiryo (The Journal of Therapy) 77: 1646-57 (1995).

Usuki, S., Usuki, Y., Tanaka, J. & Kawakura, Y. Effects of tokishakuyakusan, keishibukuryogan, shakuyakukanzoto and unkeito on ovarian endothelin, renin and angiotensin II in pregnant mare’s serum gonadotropin-treated immature rats. The American journal of Chinese medicine 20, 175-179 (1992).

Usuki, S., Tanaka, J., Kawakura, Y. & Usuki, Y. A proposal of ovarian ERAANPS (endothelin-renin-angiotensin-atrial natriuretic peptide system) and effects of tokishakuyakusan, keishibukuryogan, shakuyakukanzoto and unkeito on the ERAANPS. The American journal of Chinese medicine 20, 65-74 (1992).

Usuki, S. Effects of Tokishakuyakusan, Keishibukuryogan and Unkeito on DNA polymerase alpha activity in PMS-treated immature rat uterus incubated in vitro. The American journal of Chinese medicine 20, 265-268 (1992).

Itoh T, Terasawa K, Kohta K, et al. Effect of Keishi-bukuryo-gan and trapidil on the microcirculation in patients with cerebro-spinal vascular disease. Wakan Iyaku Gakkaishi (Journal of Medical and Pharmaceutical Society for WAKAN-YAKU) 9: 40-6 (1992).

Ohta H, Nemoto K. Preventive effect of 1-hydroxyvitamin D3 plus Kampo medicine combination therapy on osteopenia following oophorectomy – comparison between keishibukuryogan and tokishakuyakusan. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 7: 65-70 (1990).

Inoue M. Kampo therapy for mastitis – shigyakusan -*. Kampo Igaku (Kampo Medicine) 14: 132-6 (1990).

Ohta H, Nemoto K. Effect of concurrent administration of active vitamin D3 and TSUMURA Keishibukuryogan on osteopenia following oophorectomy. Kampo Igaku (Kampo Medicine) 13: 173-9 (1989).