Juzentaihoto

Jyuzentaihoto1

Chinese: Shi Quan Da Bu Tang

English: All-Inclusive Great Tonifying Decoction

Source: Taipinghuiminhejijufang (Prescriptions from the Great Peace Imperial Grace Pharmacy)

Pulse: sunken, fine, weak

Tongue: pale, swollen body, thin white fur

Abdomen: medium abdominal wall strength

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Fatigue
  • Poor appetite
  • Anemia
  • Cough
  • Pale complexion
  • Shortness of breath
  • Cold extremities
  • Spermatorrhea
  • Postpartum weakness

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

 

Herbs in This Formula

 

Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.

 

Basic and Clinical Research on Juzentaihoto – Updated on June 16, 2012

Munakata K, Takashima K, Nishiyama M, Asano N, Mase A, Hioki K, et al. Microarray analysis on germfree mice elucidates the primary target of a traditional Japanese medicine juzentaihoto: acceleration of IFN-alpha response via affecting the ISGF3-IRF7 signaling cascade. BMC genomics. 2012;13:30.

Matsuda T, Maekawa K, Asano K, Hisamitsu T. Suppressive effect of juzen-taiho-to on lung metastasis of b16 melanoma cells in vivo. Evid Based Complement Alternat Med. 2011:743153.

Ishikawa S, Ishikawa T, Asano K, Fujiwara H, Okada M, Sunagawa M, et al. Suppressive effect of juzentaihoto on vascularization induced by b16 melanoma cells in vitro and in vivo. Evid Based Complement Alternat Med. 2011;2012:945714.

Hara H, Kataoka S, Anan M, Ueda A, Mutoh T, Tabira T. The therapeutic effects of the herbal medicine, Juzen-taiho-to, on amyloid-beta burden in a mouse model of Alzheimer’s disease. J Alzheimers Dis. 2010;20(2):427-39.

Chino A, Okamoto H, Hirasaki Y, Terasawa K. A case of atopic dermatitis successfully treated with juzentaihoto (Kampo). Alternative therapies in health and medicine. 2010;16(1):62-4.

Maruyama Y, Hoshida S, Furukawa M, Ito M. Effects of Japanese herbal medicine, Juzen-taiho-to, in otitis-prone children–a preliminary study. Acta oto-laryngologica. 2009;129(1):14-8.

Kishida Y, Nishii T, Inoue T, Nishida S, Arimitsu J, Yoshikawa H, et al. Juzentaihoto (TJ-48), a traditional Japanese herbal medicine, influences hemoglobin recovery during preoperative autologous blood donation and after hip surgery. International journal of clinical pharmacology and therapeutics. 2009;47(12):716-21.

Nagai Y, Hasegawa M, Tago O, et al. Assessment of the therapeutic effect of Juzentaihoto on pressure ulcer. Kampo to Saishin-chiryo (Kampo & The Newest Therapy) 2009; 18: 143-9.

Nakamoto H, Mimura T, Honda N. Orally administrated Juzen-taiho-to/TJ-48 ameliorates erythropoietin (rHuEPO)-resistant anemia in patients on hemodialysis. Hemodialysis International 2008; 12: S9-14.

Tsuchiya M, Kono H, Matsuda M, Fujii H, Rusyn I. Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress. International journal of cancer. 2008;123(11):2503-11.

Liu H, Wang J, Sekiyama A, Tabira T. Juzen-taiho-to, an herbal medicine, activates and enhances phagocytosis in microglia/macrophages. The Tohoku journal of experimental medicine. 2008;215(1):43-54.

Fujiki K, Nakamura M, Matsuda T, Isogai M, Ikeda M, Yamamoto Y, et al. IL-12 and IL-18 induction and subsequent NKT activation effects of the Japanese botanical medicine Juzentaihoto. International journal of molecular sciences. 2008;9(7):1142-55.

Kato M, Ishige A, Anjiki N, Yamamoto M, Irie Y, Taniyama M, et al. Effect of herbal medicine Juzentaihoto on hepatic and intestinal heat shock gene expression requires intestinal microflora in mouse. World J Gastroenterol. 2007;13(16):2289-97.

Aoe H. Effect of Juzen-taiho-to on haematological recovery from predeposit autologous blood donation. Pharma Medica 2007; 25: 11-4 (in Japanese).

Sasaki K, Takasaka H, Furuhata T, et al. Effect of Kampo medicine on cancer chemotherapy. Geka Chiryo (Surgical Therapy) 2007; 97: 504-10 (in Japanese)

Sasaki K, Ezoe E, Araya J, et al. Effects of Kampo medicine on the immune Functions in gastroenteric cancer patients. Kampo to Saishin-chiryo (Kampo & the Newest Therapy) 2006; 15: 9-14 (in Japanese).

Kogure T, Ltoh K, Tatsumi T, Sekiya N, Sakai S, Shimada Y, et al. The effect of Juzen-taiho-to/TJ-48 on the expression of killer-cell immunoglobulin-like receptors (CD158a/b) on peripheral lymphocytes in vitro experiment. Phytomedicine. 2005;12(5):327-32.

Kamiyama H, Takano S, Ishikawa E, Tsuboi K, Matsumura A. Anti-angiogenic and immunomodulatory effect of the herbal medicine “Juzen-taiho-to” on malignant glioma. Biological & pharmaceutical bulletin. 2005;28(11):2111-6.

Chino A, Sakurai H, Choo MK, Koizumi K, Shimada Y, Terasawa K, et al. Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages. International immunopharmacology. 2005;5(5):871-82.

Anjiki N, Hoshino R, Ohnishi Y, Hioki K, Irie Y, Ishige A, et al. A Kampo formula Juzen-taiho-to induces expression of metallothioneins in mice. Phytother Res. 2005;19(10):915-7.

Tagami K, Niwa K, Lian Z, Gao J, Mori H, Tamaya T. Preventive effect of Juzen-taiho-to on endometrial carcinogenesis in mice is based on Shimotsu-to constituent. Biological & pharmaceutical bulletin. 2004;27(2):156-61.

Sho Y, Fujisaki K, Sakashita H, Yamaguchi K, Tahara K, Kubozono O, et al. Orally administered Kampo medicine, Juzen-taiho-to, ameliorates anemia during interferon plus ribavirin therapy in patients with chronic hepatitis C. Journal of gastroenterology. 2004;39(12):1202-4.

Du X, Liu L, Zhang YH. [Effect of association of Shiquandabu Tang with Hetaokun on liver and immunity of tumour mouse]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2004;29(5):449-51.

Yamada T. Randomized controlled trial of the efficacy of juzentaihoto (TJ-48) combined with oral 5-FU for gastric cancer. Progress in Medicine 2004; 24: 2746-7 (in Japanese)

Aoe H, Ota M, Kawahara N, et al. Effects of juzentaihoto in preoperative autologous blood pooling. Rinsho Kensa (Journal of Medical Technology) 2003; 47: 395-9 (in Japanese).

Kawakami S, Nishimura J, Umeki M, et al. Kampo therapy for feeling of lactation deficiency. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 2003; 20: 140-3.

Miyagami M, Katayama Y. [Improvement of host-immunity by adjuvant therapy with juzen-taiho-to for patients with brain tumors]. No shinkei geka. 2003;31(4):401-9.

Mita Y, Dobashi K, Shimizu Y, Nakazawa T, Mori M. Surface expression of toll-like receptor 4 on THP-1 cells is modulated by Bu-Zhong-Yi-Qi-Tang and Shi-Quan-Da-Bu-Tang. Methods and findings in experimental and clinical pharmacology. 2002;24(2):67-70.

Lian Z, Niwa K, Gao J, Tagami K, Hashimoto M, Yokoyama Y, et al. Shimotsu-to is the agent in Juzen-taiho-to responsible for the prevention of endometrial carcinogenesis in mice. Cancer letters. 2002;182(1):19-26.

Kiyohara H, Matsumoto T, Yamada H. Intestinal immune system modulating polysaccharides in a Japanese herbal (Kampo) medicine, Juzen-Taiho-To. Phytomedicine. 2002;9(7):614-24.

Hisha H, Kohdera U, Hirayama M, Yamada H, Iguchi-Uehira T, Fan TX, et al. Treatment of Shwachman syndrome by Japanese herbal medicine (Juzen-taiho-to): stimulatory effects of its fatty acids on hemopoiesis in patients. Stem cells (Dayton, Ohio). 2002;20(4):311-9.

Higuchi K, Shimizu Y, Yasumura S, et al. Preventive effect of liver carcinogenesis by Juzen-Taiho-To in the patients with liver cirrhosis. Kan-Tan-Sui 2002; 44: 341-6 (in Japanese)

Takamatsu K, Musha C, Okano H, et al. Study of usefulness of Kampo therapy for climacteric disorders. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 2002; 19: 111-6 (in Japanese).

Niwa K, Hashimoto M, Morishita S, Lian Z, Tagami K, Mori H, et al. Preventive effects of Juzen-taiho-to on N-methyl-N-nitrosourea and estradiol-17beta-induced endometrial carcinogenesis in mice. Carcinogenesis. 2001;22(4):587-91.

Dai Y, Kato M, Takeda K, Kawamoto Y, Akhand AA, Hossain K, et al. T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice. The Journal of investigative dermatology. 2001;117(3):694-701.

Saiki I. A Kampo medicine “Juzen-taiho-to”–prevention of malignant progression and metastasis of tumor cells and the mechanism of action. Biological & pharmaceutical bulletin. 2000;23(6):677-88.

Muraishi Y, Mitani N, Yamaura T, Fuse H, Saiki I. Effect of interferon-alpha A/D in combination with the Japanese and Chinese traditional herbal medicine juzen-taiho-to on lung metastasis of murine renal cell carcinoma. Anticancer research. 2000;20(5A):2931-7.

Matsumoto T, Yamada H. Orally administered Kampo (Japanese herbal) medicine, “Juzen-Taiho-To” modulates cytokine secretion in gut associated lymphoreticular tissues in mice. Phytomedicine. 2000;6(6):425-30.

Matsumoto T, Sakurai MH, Kiyohara H, Yamada H. Orally administered decoction of Kampo (Japanese herbal) medicine, “Juzen-Taiho-To” modulates cytokine secretion and induces NKT cells in mouse liver. Immunopharmacology. 2000;46(2):149-61.

Kiyohara H, Matsumoto T, Yamada H. Lignin-carbohydrate complexes: intestinal immune system modulating ingredients in kampo (Japanese herbal) medicine, juzen-taiho-to. Planta medica. 2000;66(1):20-4.

Kawamata H, Ochiai H, Mantani N, Terasawa K. Enhanced expression of inducible nitric oxide synthase by Juzen-taiho-to in LPS-activated RAW264.7 cells, a murine macrophage cell line. The American journal of Chinese medicine. 2000;28(2):217-26.

Aoe H, Matsuo T, Ebisutani M, et al. Effects of juzentaihoto (ten strong tonic herbs decoction) on presurgical autologous blood pooling in cancer patients. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 2000; 17: 67-71 (in Japanese).

Higuchi K, Watanabe A. Study on liver cancer-preventive effect of juzentaihoto in patients with liver cirrhosis. Methods in Kampo Pharmacology 2000; 5: 29-33 (in Japanese).

Saiki I, Yamaura T, Ohnishi Y, Hayakawa Y, Komatsu Y, Nunome S. HPLC analysis of juzen-taiho-to and its variant formulations and their antimetastatic efficacies. Chemical & pharmaceutical bulletin. 1999;47(8):1170-4.

Iijima K, Sun S, Cyong JC, Jyonouchi H. Juzen-taiho-to, a Japanese herbal medicine, modulates type 1 and type 2 T cell responses in old BALB/c mice. The American journal of Chinese medicine. 1999;27(2):191-203.

Aoe H, Sumida Y, Kawahara N, et al. Efficacy of an erythropoietin preparation and Kampo medicines in preoperative autologous blood donation in cancer patients. Jikoketsu Yuketsu (Journal of Japanese Society of Autologous Blood Transfusion) 1999; 12: 100-4 (in Japansese).

Toda T, Matsuzaki K, Kawano T, et al. Preoperative and postoperative combination therapy with slow-release tegafur capsules and Juzen-taiho-to in patients with colorectal cancer – Tissue concentrations and thymidine phosphorylase activity -. Gan no Rinsho (Japanese Journal of Cancer Clinics) 1998; 44:317-23.

Fujiwara M, Koumoto Y. Effect of juzentaihoto on myelosuppression due to chemotherapy for gynecologic malignant tumor. Sanfujinka Kampo Kenkyu no Ayumi (Recent Progress of Kampo Medicine in Obstetrics and Gynecology) 1998; 15: 86-9 (in Japanese).

Wu Y, Zhang Y, Wu JA, Lowell T, Gu M, Yuan CS. Effects of Erkang, a modified formulation of Chinese folk medicine Shi-Quan-Da-Bu-Tang, on mice. Journal of ethnopharmacology. 1998;61(2):153-9.

Onishi Y, Yamaura T, Tauchi K, Sakamoto T, Tsukada K, Nunome S, et al. Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-to constituents. Biological & pharmaceutical bulletin. 1998;21(7):761-5.

Ohnishi Y, Fujii H, Hayakawa Y, Sakukawa R, Yamaura T, Sakamoto T, et al. Oral administration of a Kampo (Japanese herbal) medicine Juzen-taiho-to inhibits liver metastasis of colon 26-L5 carcinoma cells. Jpn J Cancer Res. 1998;89(2):206-13.

Abe S, Tansho S, Ishibashi H, Inagaki N, Komatsu Y, Yamaguchi H. Protective effect of oral administration of a traditional medicine, Juzen-Taiho-To, and its components on lethal Candida albicans infection in immunosuppressed mice. Immunopharmacology and immunotoxicology. 1998;20(3):421-31.

Hisha H, Yamada H, Sakurai MH, Kiyohara H, Li Y, Yu C, et al. Isolation and identification of hematopoietic stem cell-stimulating substances from Kampo (Japanese herbal) medicine, Juzen-taiho-to. Blood. 1997;90(3):1022-30.

Konno H, Maruo Y, Baba S, et al. Improvement of host-immunity by Juzen-taiho-to in the postoperative adjuvant chemotherapy for patients with gastric cancer. Biotherapy 1997; 11: 193-9.

Ohnishi Y, Fujii H, Kimura F, Mishima T, Murata J, Tazawa K, et al. Inhibitory effect of a traditional Chinese medicine, Juzen-taiho-to, on progressive growth of weakly malignant clone cells derived from murine fibrosarcoma. Jpn J Cancer Res. 1996;87(10):1039-44.

Akagawa G, Abe S, Tansho S, Uchida K, Yamaguchi H. Protection of C3H/HE J mice from development of Candida albicans infection by oral administration of Juzen-taiho-to and its component, Ginseng radix: possible roles of macrophages in the host defense mechanisms. Immunopharmacology and immunotoxicology. 1996;18(1):73-89.

Sugiyama K, Ueda H, Ichio Y, Yokota M. Improvement of cisplatin toxicity and lethality by juzen-taiho-to in mice. Biological & pharmaceutical bulletin. 1995;18(1):53-8.

Sugiyama K, Ueda H, Ichio Y. Protective effect of juzen-taiho-to against carboplatin-induced toxic side effects in mice. Biological & pharmaceutical bulletin. 1995;18(4):544-8.

Kiyohara H, Matsumoto T, Takemoto N, Kawamura H, Komatsu Y, Yamada H. Effect of oral administration of a pectic polysaccharide fraction from a kampo (Japanese herbal) medicine “juzen-taiho-to” on antibody response of mice. Planta medica. 1995;61(5):429-34.

Kiyohara H, Matsumoto T, Komatsu Y, Yamada H. Protective effect of oral administration of a pectic polysaccharide fraction from a Kampo (Japanese herbal) medicine “Juzen-Taiho-To” on adverse effects of cis-diaminedichloroplatinum. Planta medica. 1995;61(6):531-34.

Suzuki S, Abe R, Nomizu T, et al. Effect of juzentaihoto (TJ-48) on leukopenia in patients receiving cancer chemotherapy. Progress in Medicine 1995; 15: 1968-71 (in Japanese).

Hasegawa T, Yamaki K, Muraoka I, et al. Effects of traditional Chinese medicines on pharmacokinetics of levofloxacin. Antimicrobial Agents and Chemotherapy 1995; 39: 2135-37.

Kosaka A, Kamiya T, Sumiyama M, et al. Usefulness of TSUMURA Juzentaihoto (TJ-48) for reducing adverse effects of anticancer drugs and improving QOL.  Progress in Medicine 1994; 14: 2259-64 (in Japanese).

Tatsuta M, Iishi H, Baba M, Nakaizumi A, Uehara H. Inhibition by shi-quan-da-bu-tang (TJ-48) of experimental hepatocarcinogenesis induced by N-nitrosomorpholine in Sprague-Dawley rats. Eur J Cancer. 1994;30A(1):74-8.

Takemoto N, Kiyohara H, Maruyama H, Komatsu Y, Yamada H, Kawamura H. A novel type of B-cell mitogen isolated from juzen-taiho-to (TJ-48), a Japanese traditional medicine. International journal of immunopharmacology. 1994;16(11):919-29.

Kosaka A, Hojyo M, Osaku M, et al. The value of TSUMURA Juzentaihoto (TJ-48) in reducing adverse effects of anticancer drugs from the perspective of QOL improvement. Progress in Medicine 1993; 13: 1072-9 (in Japanese)

Nagatomo H, Shigehira M. Efficacy of TSUMURA Juzentaihoto for reducing the adverse effects of the anticancer drug cisplatin. Kampo Igaku (Kampo Medicine) 1992; 16: 116-9 (in Japanese)

Fukui I, Gotoh S, Kihara K, et al. Adjuvant chemotherapy for invasive bladder cancer: multicenter study. Nippon Hinyokika Gakkai Zasshi (Japanese Journal of Urology) 1992; 83: 1633-9.

Yamada T. Clinical study of Juzen-taiho-to administration for postoperative esophageal carcinoma, gastric carcinoma, and colorectal carcinoma — Influence of surgical intervention and postoperative chemotherapy on cell mediated immunity—. Wakan Iyaku Gakkaishi (Journal of Medical and Pharmaceutical Society for WAKAN-YAKU) 1992; 9: 157-64.

Zee-Cheng RK. Shi-quan-da-bu-tang (ten significant tonic decoction), SQT. A potent Chinese biological response modifier in cancer immunotherapy, potentiation and detoxification of anticancer drugs. Methods and findings in experimental and clinical pharmacology. 1992;14(9):725-36.

Yamada H, Kiyohara H, Takemoto N, Zhao JF, Kawamura H, Komatsu Y, et al. Mitogenic and complement activating activities of the herbal components of juzen-taiho-to. Planta medica. 1992;58(2):166-70.

Sakamoto S, Kudo H, Kuwa K, Suzuki S, Kato T, Kawasaki T, et al. Anticancer effects of a Chinese herbal medicine, juzen-taiho-to, in combination with or without 5-fluorouracil derivative on DNA-synthesizing enzymes in 1,2-dimethylhydrazine induced colonic cancer in rats. The American journal of Chinese medicine. 1991;19(3-4):233-41.

Kiyohara H, Takemoto N, Komatsu Y, Kawamura H, Hosoya E, Yamada H. Characterization of mitogenic pectic polysaccharides from kampo (Japanese herbal) medicine “juzen-taiho-to”. Planta medica. 1991;57(3):254-9.

Yamada H, Kiyohara H, Cyong JC, Takemoto N, Komatsu Y, Kawamura H, et al. Fractionation and characterization of mitogenic and anti-complementary active fractions from kampo (Japanese Herbal) medicine “juzen-taiho-to”. Planta medica. 1990;56(4):386-91.

Hashimoto S, Tanaka Y. Adverse reactions to cancer radiotherapy. Sanfujinka no Sekai (World of Obstetrics and Gynecology) 1990; 42 suppl: 176-84 (in Japanese).

Yamada H. [Chemical characterization and biological activity of the immunologically active substances in Juzen-taiho-to (Japanese kampo prescription)]. Gan to kagaku ryoho. 1989;16(4 Pt 2-2):1500-5.

Imamichi T, Hayashi K, Nakamura T, Kaneko K, Koyama J. A Chinese traditional medicine, juzentaihoto, inhibits the O2- generation by macrophages. Journal of pharmacobio-dynamics. 1989;12(11):693-9.

Sakagami Y, Mizoguchi Y, Miyajima K, Kuboi H, Kobayashi K, Kioka K, et al. [Antitumor activity of shi-quan-da-bu-tang and its effects on interferon-gamma and interleukin 2 production]. Arerugi = [Allergy]. 1988;37(1):57-60.

Iijima OT, Fujii Y, Kobayashi Y, Kuboniwa H, Murakami C, Sudo K, et al. [Protective effects of juzen-taiho-to on the adverse effects of mitomycin C]. Nihon Gan Chiryo Gakkai shi. 1988;23(6):1277-82.

Tanaka Y, Hashimoto S. Effects of TSUMURA Juzentaihoto on various complaints occurring as adverse reactions during radiotherapy. JAMA (Japanese version) 1988; (6) suppl: 70-1 (in Japanese).

Aburada M, Takeda S, Ito E, Nakamura M, Hosoya E. Protective effects of juzentaihoto, dried decoctum of 10 Chinese herbs mixture, upon the adverse effects of mitomycin C in mice. Journal of pharmacobio-dynamics. 1983;6(12):1000-4.