{"id":2636,"date":"2012-06-06T11:18:58","date_gmt":"2012-06-06T15:18:58","guid":{"rendered":"http:\/\/kampo.ca\/herbs-formulas\/?page_id=2636"},"modified":"2014-03-19T20:40:50","modified_gmt":"2014-03-20T00:40:50","slug":"chotosan","status":"publish","type":"page","link":"https:\/\/kampo.ca\/herbs-formulas\/formulas\/chotosan\/","title":{"rendered":"Chotosan"},"content":{"rendered":"

\"chotosan\"<\/p>\n

Chinese:<\/strong> Gou Teng San<\/p>\n

English:<\/strong> Uncaria Decoction<\/p>\n

Source:<\/strong>\u00a0Pujibenshifang (Moxibustion in\u00a0Prescriptions\u00a0for Universal<\/a>\u00a0Relief)<\/a><\/p>\n

Pulse:<\/strong>\u00a0bowstring, rapid<\/p>\n

Tongue:<\/strong>\u00a0red,body, greasy fur<\/p>\n

Abdomen:<\/strong>\u00a0shinkahiko<\/a><\/p>\n

Indications:<\/strong> This herbal formula has been used for patients with following health conditions and symptoms:<\/p>\n

Member Section<\/em><\/p>\n

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.<\/p>\n

Herbs in This Formula<\/strong><\/p>\n

member only contents<\/p>\n

Basic and Clinical Research on Chotosan<\/strong> <\/strong>\u2013 Updated on June 16, 2012<\/p>\n

Zhao Q, Yokozawa T, Tsuneyama K, Tanaka K, Miyata T, Shibahara N, et al. Chotosan (Diaoteng San)-induced improvement of cognitive deficits in senescence-accelerated mouse (SAMP8) involves the amelioration of angiogenic\/neurotrophic factors and neuroplasticity systems in the brain. Chinese medicine. 2011;6:33.<\/p>\n

Zhao Q, Murakami Y, Tohda M, Obi R, Shimada Y, Matsumoto K. Chotosan, a kampo formula, ameliorates chronic cerebral hypoperfusion-induced deficits in object recognition behaviors and central cholinergic systems in mice. Journal of pharmacological sciences. 2007;103(4):360-73.<\/p>\n

Obi R, Tohda M, Zhao Q, Obi N, Hori H, Murakami Y, et al. Chotosan enhances macrophage colony-stimulating factor mRNA expression in the ischemic rat brain and C6Bu-1 glioma cells. Biological & pharmaceutical bulletin. 2007;30(12):2250-6.<\/p>\n

Terasawa K. Chotosan in the treatment of vascular dementia. Pharma Medica<\/em> 2007; 25: 57-9 (in Japanese).<\/p>\n

Suzuki T, Futami S, Igari Y, Matsumura N, Watanabe K, Nakano H, et al. A Chinese herbal medicine, choto-san, improves cognitive function and activities of daily living of patients with dementia: a double-blind, randomized, placebo-controlled study<\/a>. Journal of the American Geriatrics Society. 2005;53(12):2238-40.<\/p>\n

Zhao Q, Murakami Y, Tohda M, Watanabe H, Matsumoto K. Preventive effect of chotosan, a Kampo medicine, on transient ischemia-induced learning deficit is mediated by stimulation of muscarinic M1 but not nicotinic receptor. Biological & pharmaceutical bulletin. 2005;28(10):1873-8.<\/p>\n

Murakami Y, Zhao Q, Harada K, Tohda M, Watanabe H, Matsumoto K. Choto-san, a Kampo formula, improves chronic cerebral hypoperfusion-induced spatial learning deficit via stimulation of muscarinic M1 receptor. Pharmacology, biochemistry, and behavior. 2005;81(3):616-25.<\/p>\n

Hayashi H, Tohda M, Watanabe H, Murakami Y, Matsumoto K. The effects of Choto-san on the mRNA expression of Alzheimer’s disease related factors in the permanent ischemic rat brain. Biological & pharmaceutical bulletin. 2005;28(4):744-6.<\/p>\n

Mahakunakorn P, Tohda M, Murakami Y, Watanabe H, Matsumoto K. Effects of Choto-san and its related constituents on endogenous antioxidant systems. Biological & pharmaceutical bulletin. 2005;28(1):53-7.<\/p>\n

Yokoyama K, Shimada Y, Hori E, Nakagawa T, Takagi S, Sekiya N, et al. Effects of Choto-san and hooks and stems of Uncaria sinensis on antioxidant enzyme activities in the gerbil brain after transient forebrain ischemia. Journal of ethnopharmacology. 2004;95(2-3):335-43.<\/p>\n

Yokoyama K, Shimada Y, Hori E, Sekiya N, Goto H, Sakakibara I, et al. Protective effects of Choto-san and hooks and stems of Uncaria sinensis against delayed neuronal death after transient forebrain ischemia in gerbil. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2004;11(6):478-89.<\/p>\n

Dohi K, Aruga T, Satoh K, Shioda S. Choto-san (kampo Medicine) for the treatment of headache. Headache. 2004;44(4):375.<\/p>\n

Dohi K, Satoh K, Ikeda Y, Ohtaki H, Shioda S, Aruga T. Neuroprotective effect from ischemia and direct free radical scavenging activity of Choto-san (kampo medicine). Acta neurochirurgica Supplement. 2003;86:123-7.<\/p>\n

Mahakunakorn P, Tohda M, Murakami Y, Matsumoto K, Watanabe H. Antioxidant and free radical-scavenging activity of Choto-san and its related constituents. Biological & pharmaceutical bulletin. 2004;27(1):38-46.<\/p>\n

Yamaguchi S, Matsubara M, Kobayashi S. Event-related brain potential changes after Choto-san administration in stroke patients with mild cognitive impairments. Psychopharmacology. 2004;171(3):241-9.<\/p>\n

Watanabe H, Zhao Q, Matsumoto K, Tohda M, Murakami Y, Zhang SH, et al. Pharmacological evidence for antidementia effect of Choto-san (Gouteng-san), a traditional Kampo medicine. Pharmacology, biochemistry, and behavior. 2003;75(3):635-43.<\/p>\n

Mizushima Y, Kan S, Yoshida S, Irie Y, Urata Y. Effect of Choto-san, a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse (SAM). Phytotherapy research : PTR. 2003;17(5):542-5.<\/p>\n

Shimada Y, Yang Q, Yokoyama K, Goto H, Kasahara Y, Sekiya N, et al. Choto-san prevents occurrence of stroke and prolongs life span in stroke-prone spontaneously hypertensive rats. The American journal of Chinese medicine. 2003;31(1):79-85.<\/p>\n

Sekiya N, Shimada Y, Shibahara N, Takagi S, Yokoyama K, Kasahara Y, et al. Inhibitory effects of Choto-san (Diao-teng-san), and hooks and stems of Uncaria sinensis on free radical-induced lysis of rat red blood cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2002;9(7):636-40. Epub 2002\/12\/19.<\/p>\n

Yang Q, Goto H, Shimada Y, Kita T, Shibahara N, Terasawa K. Effects of Choto-san on hemorheological factors and vascular function in stroke-prone spontaneously hypertensive rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2002;9(2):93-8.<\/p>\n

Goto H, Yang Q, Kita T, Hikiami H, Shimada Y, Terasawa K. Effects of Choto-san on microcirculation, serum nitric oxide and lipid peroxides in patients with asymptomatic cerebral infarction. The American journal of Chinese medicine. 2001;29(1):83-9<\/p>\n

Sugimoto A, Goto K, Ishige A, Komatsu Y, Miyamoto KI. Effect of Choto-san, a Kampo medicine, on the cerebral blood flow autoregulation in spontaneously hypertensive rats. Japanese journal of pharmacology. 2000;83(2):135-42.<\/p>\n

Itoh T, Shimada Y, Terasawa K. Efficacy of Choto-san on vascular dementia and the protective effect of the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death. Mechanisms of ageing and development. 1999;111(2-3):155-73.<\/p>\n

Yuzurihara M, Goto K, Sugimoto A, Ishige A, Komatsu Y, Shimada Y, et al. Effect of Choto-san, a kampo medicine, on impairment of passive avoidance performance in mice. Phytotherapy research : PTR. 1999;13(3):233-5<\/p>\n

Mimaki Y, Toshimizu N, Yamada K, Sashida Y. [Anti-convulsion effects of choto-san and chotoko (Uncariae Uncis cam Ramlus) in mice, and identification of the active principles]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1997;117(12):1011-21.<\/p>\n

Nishizawa Y, Nishizawa Y, Fushiki S. Analgesic effects on headache in patients with spinal cord injury. Nippon Zutsu Gakkaishi <\/em>(Japanese Journal of Headache<\/em>) 1997; 25: 23-6.<\/p>\n

Terasawa K, Shimada Y, Kita T, et al. Choto-san in the treatment of vascular dementia: A double blind, placebo-controlled study. Phytomedicine<\/em> 1997; 4: 15-22.<\/p>\n

Narumi J, Kohsaka S, Miyazawa S, et al. Evaluation of the Kampo monotreatment for hypertensive patients using ambulatory blood pressure monitoring. Kampo Shinryo<\/em> 1996; 15: 34-5 (in Japanese).<\/p>\n

Matsushita S, Ueda S, Ouchi Y, et al. Usefulness of chotosan (TJ-47) for relieving the accompanying symptoms and sequelae of cerebrovascular disease, chronic cerebrovascular insufficiency, or hypertension. Geriatric Medicine<\/em> 1995; 33: 1333-41 (in Japanese).<\/p>\n

Shimada Y, Terasawa K, Yamamoto T, et al. A well-controlled study of Choto-san and placebo in the treatment of vascular dementia. Wakan Iyakugaku Zasshi <\/em>(Journal of Traditional Medicines<\/em>) 1994; 11: 246-55.<\/p>\n

Shimada Y, Terasawa K, Yamamoto T, et al. Efficacy of Choto-san on vascular dementia: A well, placebo-controlled study. Wakan Iyakugaku Zasshi <\/em>(Journal of Traditional Medicines<\/em>) 1994; 11: 370-1 (in Japanese).<\/p>\n

Narumi J, Kohsaka S, Miyazawa S, et al. Evaluation of the Kampo monotreatment for hypertensive patients using ambulatory blood pressure monitor. Wakan Iyakugaku Zasshi <\/em>(Journal of Traditional Medicines<\/em>) 1994; 11: 282-3 (in Japanese).<\/p>\n

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