{"id":282,"date":"2010-09-22T18:55:42","date_gmt":"2010-09-22T22:55:42","guid":{"rendered":"http:\/\/kampo.ca\/herbs-formulas\/"},"modified":"2015-07-25T17:33:43","modified_gmt":"2015-07-25T21:33:43","slug":"rikkunshito","status":"publish","type":"page","link":"https:\/\/kampo.ca\/herbs-formulas\/formulas\/rikkunshito\/","title":{"rendered":"Rikkunshito"},"content":{"rendered":"<!--CusAds0--><p><img loading=\"lazy\" decoding=\"async\" title=\" Liu Jun Zi Tang - Six-Gentleman Decoction\" onmouseup=\"hl2l(event);\" alt=\"Rikkunshito\" src=\"http:\/\/kampo.ca\/herbs-formulas\/wp-content\/uploads\/2010\/09\/Rikkunshito1.jpg\" width=\"448\" height=\"314\" \/><\/p>\n<p><strong>Chinese:<\/strong> Liu Jun Zi Tang<\/p>\n<p><strong>English:<\/strong> Six-Gentleman Decoction<\/p>\n<p><strong>Source:<\/strong> <em>Jiao zhu fu ren liang fang<\/em> (Revised Five Formulas for Women)<\/p>\n<p><strong>Pulse:<\/strong> weak vacuous, slippely vacuous<\/p>\n<p><strong>Tongue:<\/strong> pale body, wet white greasy fur<\/p>\n<p><strong>Abdomen: <\/strong><a href=\"http:\/\/kampo.ca\/herbs-formulas\/diagnosis\/abdominal-diagnosis\/diagnosisabdominal-diagnosisstomach-splashing-sound-shinsuion\/\">shinsuion<\/a>, <a href=\"http:\/\/kampo.ca\/herbs-formulas\/diagnosis\/abdominal-diagnosis\/midline-lead\/\">midline lead<\/a><\/p>\n<p><strong>Indications: <\/strong>This herbal formula has been used for patients with following health conditions and symptoms:<\/p>\n<ul>\n<li>Poor appetite<\/li>\n<li>Loose stools<\/li>\n<li>Diarrhea<\/li>\n<li>Indigestion<\/li>\n<li>Heart burn<\/li>\n<li>Nausea<\/li>\n<li>Bloating (epigastric region)<\/li>\n<li>Fatigue<\/li>\n<\/ul>\n<p>There are many other health conditions that may respond well to this herbal formula, in particular, patients exhibiting indicative traditional diagnostic signs and symptoms.<\/p>\n<p><strong>Herbs in This Formula<\/strong><\/p>\n<ul>\n<li><a style=\"font-size: 16px;\" title=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/hange\/\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/hange\/\">Hange (Pinelliae Rhizoma)<\/a><span style=\"font-size: 16px;\">\u00a04g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/bukuryo\/\">Bukuryo (Sclerotium Poriae Cocos)<\/a><span style=\"font-size: 16px;\">, 3g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" title=\"kanzo\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/kanzo\/\">Kanzo (Glycyrrhizae Radix)<\/a><span style=\"font-size: 16px;\">, 1g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" title=\"ninjin\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/ninjin\/\">Ninjin\u00a0(Ginseng Radix)<\/a><span style=\"font-size: 16px;\">, 2g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/chinpi\/\">Chinpi<\/a><span style=\"font-size: 16px;\"> (<\/span><a style=\"font-size: 16px;\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/chinpi\/\">Citri reticulatae Pericarpium<\/a><span style=\"font-size: 16px;\">) 4g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" title=\"white atractylodes rhizome\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/byakujutsu\/\">Byakujutsu (Atractylodis macrocephalae Rhizoma)<\/a><span style=\"font-size: 16px;\">\u00a03g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" title=\"jujube fruit\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/onji\/\">Taiso (Jujubae Fructus)<\/a><span style=\"font-size: 16px;\">\u00a02g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" title=\"fresh ginger rhizome\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/shokyo\/\">Shokyo (Zingiberis Rhizoma)<\/a><span style=\"font-size: 16px;\">\u00a02g<\/span><\/li>\n<\/ul>\n<p><b>Note:<\/b>\u00a0Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient\u2019s condition, constitutional patterns, quality of the herbs, and other factors involved.<\/p>\n<p><strong>Abdominal pattern (fukusho) of Rikkunshito <\/strong>(from <a href=\"..\/diagnosis\/abdominal-diagnosis\/\"><em>Fukusho Kiran<\/em><\/a>, 1800)<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1825\" title=\"Fukusho Rikkunshito F\" alt=\"\" src=\"http:\/\/kampo.ca\/herbs-formulas\/wp-content\/uploads\/2010\/09\/Fukusho-Rikkunshito-F.jpg\" width=\"447\" height=\"500\" srcset=\"https:\/\/kampo.ca\/herbs-formulas\/wp-content\/uploads\/2010\/09\/Fukusho-Rikkunshito-F.jpg 447w, https:\/\/kampo.ca\/herbs-formulas\/wp-content\/uploads\/2010\/09\/Fukusho-Rikkunshito-F-134x150.jpg 134w, https:\/\/kampo.ca\/herbs-formulas\/wp-content\/uploads\/2010\/09\/Fukusho-Rikkunshito-F-268x300.jpg 268w\" sizes=\"auto, (max-width: 447px) 100vw, 447px\" \/><\/p>\n<p><strong>Basic and Clinical Research on Rikkunshito (<\/strong><strong>Liu Jun Zi Tang<\/strong><strong>)<\/strong> \u2013 Updated on Mar 30, 2011<\/p>\n<p>Arai, M., Matsumura, T., Yoshikawa, M., Imazeki, F. &amp; Yokosuka, O. Analysis of the Rikkunshito efficacy on patients with functional dyspepsia. <em>Nippon yakurigaku zasshi<\/em> <strong>137<\/strong>, 18-21 (2011).<\/p>\n<p>Yakabi, K.<em>, et al.<\/em> Rikkunshito and 5-HT2C receptor antagonist improve cisplatin-induced anorexia via hypothalamic ghrelin interaction. <em>Regulatory peptides<\/em> <strong>161<\/strong>, 97-105 (2010).<\/p>\n<p>Takeda, H.<em>, et al.<\/em> Rikkunshito ameliorates the aging-associated decrease in ghrelin receptor reactivity via phosphodiesterase III inhibition. <em>Endocrinology<\/em> <strong>151<\/strong>, 244-252 (2010).<\/p>\n<p>Shiratori, M., Shoji, T., Kanazawa, M., Hongo, M. &amp; Fukudo, S. Effect of rikkunshito on gastric sensorimotor function under distention. <em>Neurogastroenterol Motil<\/em> (2010).<\/p>\n<p>Miwa, H.<em>, et al.<\/em> Rikkunshito, a traditional Japanese medicine, may relieve abdominal symptoms in rats with experimental esophagitis by improving the barrier function of epithelial cells in esophageal mucosa. <em>Journal of gastroenterology<\/em> <strong>45<\/strong>, 478-487 (2010).<\/p>\n<p>Matsumura, T.<em>, et al.<\/em> The traditional Japanese medicine Rikkunshito increases the plasma level of ghrelin in humans and mice. <em>Journal of gastroenterology<\/em> <strong>45<\/strong>, 300-307 (2010).<\/p>\n<p>Kusunoki, H.<em>, et al.<\/em> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20962437?dopt=Citation\" target=\"_blank\">Efficacy of Rikkunshito, a traditional Japanese medicine (Kampo), in treating functional dyspepsia<\/a>. <em>Internal medicine (Tokyo, Japan)<\/em> <strong>49<\/strong>, 2195-2202 (2010).\u00a0 <a href=\"http:\/\/www.jstage.jst.go.jp\/article\/internalmedicine\/49\/20\/2195\/_pdf\" target=\"_blank\">Full Text PDF<\/a><\/p>\n<p>Hattori, T. Rikkunshito and ghrelin. <em>International journal of peptides<\/em> <strong>2010<\/strong>(2010).<\/p>\n<p>Tominaga, K.<em>, et al.<\/em> The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT3 Receptor Pathway in Rats. <em>Evid Based Complement Alternat Med<\/em> (2009).<\/p>\n<p>Arai M. Rikkunshito significantly enhances the secretion of ghrelin in patients with functional dyspepsia. <em>Kampo Igaku <\/em>(<em>Kampo Medicine<\/em>) <strong>33<\/strong>: 405-6 (2009).<\/p>\n<p>Takahashi T, Endo S, Nakajima K, et al. Effect of rikkunshito, a chinese herbal medicine, on stasis in patients after pylorus-preserving gastrectomy. <em>World journal of Surgery <\/em> <strong>33<\/strong>: 296-302 (2009).<\/p><!--CusAds0-->\n<p>Takahashi, T., Endo, S., Nakajima, K., Souma, Y. &amp; Nishida, T. Effect of rikkunshito, a chinese herbal medicine, on stasis in patients after pylorus-preserving gastrectomy. <em>World journal of surgery<\/em> <strong>33<\/strong>, 296-302 (2009).<\/p>\n<p>Kawahara, H.<em>, et al.<\/em> Impact of rikkunshito, an herbal medicine, on delayed gastric emptying in profoundly handicapped patients. <em>Pediatric surgery international<\/em> <strong>25<\/strong>, 987-990 (2009).<\/p>\n<p>Takeda, H.<em>, et al.<\/em> Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism. <em>Gastroenterology<\/em> <strong>134<\/strong>, 2004-2013 (2008).<\/p>\n<p>Oka T. Rikkunshito attenuates milnacipran\u2013induced adverse gastrointestinal symptoms and potentiates its antidepressant effect. <em>Medical Tribune <\/em>41:82 (2008).<\/p>\n<p>Okuno S, Hirayama K, Inoue J, et al. Effects of rikkunshito on the postoperative nausea and vomiting (PONV) after laparoscopic gynecological surgery. <em>Masui <\/em>(<em>Japanese Journal of Anesthesiology<\/em>) <strong>57<\/strong>: 1502-9 (2008).<\/p>\n<p>Kawahara, H.<em>, et al.<\/em> Effects of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux. <em>Pediatric surgery international<\/em> <strong>23<\/strong>, 1001-1005 (2007).<\/p>\n<p>Oka T, Tamagawa Y, Hayashida S, et al. Rikkunshi-to atenuates adverse gastrointestinal symptoms induced by fluvoxamine. <em>Biopsychosocial Medicine <\/em> 1: 21 (2007).<\/p>\n<p>Yamaguchi T, Koide A. Usefulness of Rikkun-shi-to (TJ-43), a Chinese herbal medicine, for the treatment of gastro-esophageal reflux disease (GERD). <em>Medical Science Digest<\/em> <strong>33<\/strong>: 748-52 (2007).<\/p>\n<p>Ozaki, M., Nagatomo, T., Maeda, T., Kishioka, S. &amp; Yamamoto, H. Pharmacological differences between Liu-Jun-Zi-Tang, a traditional Chinese herbal medicine, and domperidone on isolated guinea-pig ileum. <em>Biological &amp; pharmaceutical bulletin<\/em> <strong>29<\/strong>, 1349-1354 (2006).<\/p>\n<p>Nishida T. Effect of rikkunshito on gastrointestinal function in patients after gastrectomy. <em>Progress in Medicine <\/em> <strong>26<\/strong>: 3224-5 (2006).<\/p>\n<p>Fushiki H, Saeki A, Shiozaki A. Attempt to reduce adverse reactions associated with oral iron preparation for anemia in pregnancy by combination with rikkunshito (TJ-43). <em>Sanfujinka Kampo Kenkyu no Ayumi <\/em>(<em>Recent Progress of Kampo Medicine in Obstetrics and Gynecology<\/em>) \u00a0<strong>20<\/strong>: 138-9 (2003).<\/p>\n<p>Mizuno S, Yamagiwa K, Iwata M, et al. Effect of early treatment with TSUMURA Rikkunshito on gastrointestinal symptoms after resection of gastric cancer \u2013 focusing on reflux esophagiti. <em>Progress in Medicine <\/em> <strong>21<\/strong>: 1366-7 (2001).<\/p>\n<p>Hayakawa, T.<em>, et al.<\/em> Liu-Jun-Zi-Tang, a kampo medicine, promotes adaptive relaxation in isolated guinea pig stomachs. <em>Drugs under experimental and clinical research<\/em> <strong>25<\/strong>, 211-218 (1999).<\/p>\n<p>Harasawa S. The role of rikkunshito against NUD (non-ulcer dyspepsia) \u2013 especially its efficacy in dysmotility-like NUD. <em>Progress in Medicine<\/em> <strong>19<\/strong>: 843-8 (1999).<\/p>\n<p>Arakawa, T.<em>, et al.<\/em> Gastroprotection by Liu-Jun-Zi-Tang (TJ-43): possible mediation of nitric oxide but not prostaglandins or sulfhydryls. <em>Drugs under experimental and clinical research<\/em> <strong>25<\/strong>, 207-210 (1999).<\/p>\n<p>Hasegawa T, Yamaki K, Muraoka I, et al. Effects of traditional Chinese medicines on pharmacokinetics of levofloxacin. <em>Antimicrobial Agents and Chemotherapy <\/em> <strong>39<\/strong>: 2135-37 (1995).<\/p>\n<p>Hasegawa T, Yamaki K, Nadai M, et al. Lack of effect of Chinese medicines on bioavailability of ofloxacin in healthy volunteers. <em>International Journal of Clinical Pharmacology and Therapeutics <\/em> <strong>31<\/strong>: 57-61 (1994).<\/p>\n<p>Harasawa S, Miyoshi A, Miwa T, et al. Double-blind multicenter post-marketing clinical trial of TJ-43 TSUMURA Rikkunshi-to for the treatment of dysmotility-like dyspepsia. <em>Igaku no Ayumi <\/em>(<em>Journal of Clinical and Experimental Medicine<\/em>) <strong>187<\/strong>: 207-29 (1998).<\/p>\n<p>Tatsuta, M. &amp; Iishi, H. Effect of treatment with liu-jun-zi-tang (TJ-43) on gastric emptying and gastrointestinal symptoms in dyspeptic patients. <em>Alimentary pharmacology &amp; therapeutics<\/em> <strong>7<\/strong>, 459-462 (1993).<\/p>\n<p>Komatsuzaki O. Clinical effect of TSUMURA Rikkunshito on indefinite epigastric distress &#8211; comparison with a control agent, and assessment mainly based on the endoscopic findings and the histology of gastric mucosal biopsy specimens before and after the treatment. <em>Kampo Igaku <\/em>(<em>Kampo Medicine<\/em>) <strong>17:<\/strong> 120-31 (1993).<\/p>\n<p>Kawamura S, Okita K, Tada M, et al. Clinical comparison of TSUMURA Rikkunshito and sulpiride in the treatment of indefinite complaints of epigastric distress &#8211; mainly the antidepressive effect and the improvement of gastric emptying. <em>Progress in Medicine <\/em><strong>12<\/strong>: 1156-62 (1992).<\/p>\n<p>Miyoshi A, Kaneko E, Nakazawa S, et al. Clinical evaluation of TJ-43 TSUMURA Rikkunshito in the treatment of gastritis (acute gastritis and acute exacerbation of chronic gastritis) &#8211; multicenter comparative study using sodium azulene sulfonate as a control. <em>Shindan to Chiryo <\/em>(<em>Diagnosis and Treatment<\/em>) <strong>79<\/strong>: 789-810 (1991).<\/p>\n<p>Miyoshi A, Yachi A, Masamune O, et al. Clinical evaluation of TJ-43 TSUMURA Rikkunshito in the treatment of indefinite complaints of gastrointestinal disorders including chronic gastritis &#8211; a multicenter comparative study using cisapride as a control. <em>Progress in Medicine <\/em><strong>11<\/strong>: 1605-31 (1991).<\/p>\n<p>Ohta Y, Nishioka M, Yamamoto Y, et al. Multicenter clinical evaluation of Kampo preparations for medical use in the treatment of gastritis (acute gastritis and acute exacerbation of chronic gastritis) &#8211; comparison with gefarnate as a control. <em>Shindan to Chiryo <\/em>(<em>Diagnosis and Treatment<\/em>) \u00a0<strong>78<\/strong>: 2935-46 (1990).<\/p>\n<div class=\"1105701a103637095f64f2405c549ac8\" data-index=\"1\" style=\"float: none; margin:5px 0 5px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block; text-align:center;\"\r\n     data-ad-layout=\"in-article\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-client=\"ca-pub-3630309833918220\"\r\n     data-ad-slot=\"2018820141\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>Takemoto T, Matsuda K, Tada M, et al. Clinical evaluation of the efficacy of TJ-43 Tsumura Rikkunshi-To on gastritis with abdominal symptom &#8211; multicenter group study in comparison with cetraxate -. <em>Shokakika <\/em>(<em>Gastroenterology<\/em>) <strong>12<\/strong>: 223-34 (1990).<\/p>\n<!--CusAds0-->\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Chinese: Liu Jun Zi Tang English: Six-Gentleman Decoction Source: Jiao zhu fu ren liang fang (Revised Five Formulas for Women) Pulse: weak vacuous, slippely vacuous Tongue: pale body, wet white greasy fur Abdomen: shinsuion, midline lead Indications: This herbal formula&nbsp;&hellip; <a href=\"https:\/\/kampo.ca\/herbs-formulas\/formulas\/rikkunshito\/\">finish&nbsp;reading&nbsp;Rikkunshito<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":27,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-282","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Rikkunshito<\/title>\n<meta name=\"description\" content=\"Chinese: Liu Jun Zi Tang English: Six-Gentleman Decoction Source: Jiao zhu fu ren liang fang (Revised Five Formulas for Women) Pulse: weak vacuous,\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/kampo.ca\/herbs-formulas\/formulas\/rikkunshito\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" 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