{"id":325,"date":"2010-09-28T14:15:05","date_gmt":"2010-09-28T18:15:05","guid":{"rendered":"http:\/\/kampo.ca\/herbs-formulas\/"},"modified":"2015-07-25T17:35:26","modified_gmt":"2015-07-25T21:35:26","slug":"yokukansan","status":"publish","type":"page","link":"https:\/\/kampo.ca\/herbs-formulas\/formulas\/yokukansan\/","title":{"rendered":"Yokukansan"},"content":{"rendered":"<!--CusAds0--><p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" title=\"Yi Gan San - Restrain the Liver Powder\" onmouseup=\"hl2l(event);\" alt=\"Yokukansan\" src=\"http:\/\/kampo.ca\/herbs-formulas\/wp-content\/uploads\/2010\/09\/Yokukansan1.jpg\" width=\"448\" height=\"314\" \/><\/p>\n<p><strong>Chinese:<\/strong> Yi Gan San<\/p>\n<p><strong>English:<\/strong> Restrain the Liver Powder<\/p>\n<p><strong>Source:<\/strong> <em>Bao ying cuo yao<\/em> (Synopsis of Caring for Infants)<\/p>\n<p><strong>Pulse:<\/strong> bowstring, fine, soft<\/p>\n<p><strong>Tongue:<\/strong> red, white coating<\/p>\n<p><strong>Abdomen: <\/strong><a href=\"http:\/\/kampo.ca\/herbs-formulas\/diagnosis\/abdominal-diagnosis\/rectus-tension-fukuchokukinrenkyu\/\">fukuchokukinrenkyu<\/a>, <a href=\"http:\/\/kampo.ca\/herbs-formulas\/diagnosis\/abdominal-diagnosis\/palpitations\/\">saijyoki<\/a><\/p>\n<p><strong>Indications: <\/strong>This herbal formula has been used for patients with following health conditions and symptoms:<\/p>\n<ul>\n<li>Irritability<\/li>\n<li>Nervousness<\/li>\n<li>Easily upset<\/li>\n<li>Headache<\/li>\n<li>Dizziness<\/li>\n<li>Insomnia<\/li>\n<li>Muscle cramps<\/li>\n<li>Facial twitching<\/li>\n<li>Hands, legs tremors<\/li>\n<\/ul>\n<p>There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.<\/p>\n<p><b>Herbs in This Formula<\/b><\/p>\n<ul>\n<li><a style=\"font-size: 16px;\" title=\"white atractylodes rhizome\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/byakujutsu\/\">Byakujutsu (Atractylodis macrocephalae Rhizoma)<\/a><span style=\"font-size: 16px;\">\u00a04g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/bukuryo\/\">Bukuryo (Sclerotium Poriae Cocos)<\/a><span style=\"font-size: 16px;\">, 4g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" title=\"Senkyu\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/senkyu\/\">Senkyu (Chuanxiong Rhizoma)<\/a><span style=\"font-size: 16px;\">\u00a03g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" title=\"Chinese angelica root\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/toki\/\">Toki (Angelicae sinensis Radix)<\/a><span style=\"font-size: 16px;\">\u00a03g<\/span><\/li>\n<li><a style=\"font-size: 16px;\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/chotoko\/\">Chotoko<\/a><span style=\"font-size: 16px;\"> (<\/span><a style=\"font-size: 16px;\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/chotoko\/\">Uncariae Uncis Cum Ramulus<\/a><span style=\"font-size: 16px;\">) 3g<\/span><\/li>\n<li>\n<p style=\"display: inline !important;\"><a title=\"bupleurum root\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/saiko\/\">Saiko (Bupleuri Radix)<\/a>\u00a02g<\/p>\n<\/li>\n<li>\n<p style=\"display: inline !important;\">\n<p><a style=\"font-size: 16px;\" title=\"kanzo\" href=\"http:\/\/kampo.ca\/herbs-formulas\/herbs\/kanzo\/\">Kanzo (Glycyrrhizae Radix)<\/a>\u00a01<span style=\"font-size: 16px;\">g<\/span><\/li>\n<\/ul>\n<p><b>Note:<\/b>\u00a0Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient\u2019s condition, constitutional patterns, quality of the herbs, and other factors involved.<\/p>\n<p><strong style=\"font-size: 16px;\">Basic and Clinical Research on Yokukansan (<\/strong><strong style=\"font-size: 16px;\">Yi Gan San<\/strong><strong style=\"font-size: 16px;\">)<\/strong><span style=\"font-size: 16px;\"> \u2013 Updated on Feb. 23, 2011<\/span><\/p>\n<p>1.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Miyaoka, T.<em>, et al.<\/em> Yi-gan san for treatment of charles bonnet syndrome (visual hallucination due to vision loss): an open-label study. <em>Clinical neuropharmacology<\/em> <strong>34<\/strong>, 24-27 (2011).<\/p>\n<p>2.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Fujiwara, H.<em>, et al.<\/em> Yokukansan, a traditional Japanese medicine, ameliorates memory disturbance and abnormal social interaction with anti-aggregation effect of cerebral amyloid beta proteins in amyloid precursor protein transgenic mice. <em>Neuroscience<\/em> (2011).<\/p>\n<p>3.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Tamano, H., Kan, F., Oku, N. &amp; Takeda, A. Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice. <em>Brain research bulletin<\/em> <strong>83<\/strong>, 351-355 (2010).<\/p>\n<p>4.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Shinno, H.<em>, et al.<\/em> Successful treatment of restless legs syndrome with the herbal prescription Yokukansan. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>34<\/strong>, 252-253 (2010).<\/p>\n<p>5.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Sekiguchi, K.<em>, et al.<\/em> Effects of yokukansan and donepezil on learning disturbance and aggressiveness induced by intracerebroventricular injection of amyloid beta protein in mice. <em>Phytother Res<\/em> (2010).<\/p>\n<p>6.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Saito, S., Kobayashi, T., Osawa, T. &amp; Kato, S. Effectiveness of Japanese herbal medicine yokukansan for alleviating psychiatric symptoms after traumatic brain injury. <em>Psychogeriatrics<\/em> <strong>10<\/strong>, 45-48 (2010).<\/p>\n<p>7.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Okahara, K.<em>, et al.<\/em> Effects of Yokukansan on behavioral and psychological symptoms of dementia in regular treatment for Alzheimer&#8217;s disease. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>34<\/strong>, 532-536 (2010).<\/p>\n<p>8.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Nogami, A.<em>, et al.<\/em> Effects of yokukansan on anxiety-like behavior in a rat model of cerebrovascular dementia. <em>Journal of natural medicines<\/em> (2010).<\/p>\n<p>9.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Mizoguchi, K., Tanaka, Y. &amp; Tabira, T. Anxiolytic effect of a herbal medicine, yokukansan, in aged rats: involvement of serotonergic and dopaminergic transmissions in the prefrontal cortex. <em>Journal of ethnopharmacology<\/em> <strong>127<\/strong>, 70-76 (2010).<\/p>\n<p>10.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Mizoguchi, K., Shoji, H., Tanaka, Y. &amp; Tabira, T. Ameliorative effect of traditional Japanese medicine yokukansan on age-related impairments of working memory and reversal learning in rats. <em>Neuroscience<\/em> (2010).<\/p>\n<p>11.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kawanabe, T.<em>, et al.<\/em> Successful treatment with Yokukansan for behavioral and psychological symptoms of Parkinsonian dementia. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>34<\/strong>, 284-287 (2010).<\/p>\n<p>12.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kawakami, Z., Kanno, H., Ikarashi, Y. &amp; Kase, Y. Yokukansan, a kampo medicine, protects against glutamate cytotoxicity due to oxidative stress in PC12 cells. <em>Journal of ethnopharmacology<\/em> (2010).<\/p>\n<p>13.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kato, S.<em>, et al.<\/em> Successful treatment of chronic urticaria with a Japanese herbal medicine, yokukansan. <em>The Journal of dermatology<\/em> <strong>37<\/strong>, 1066-1067 (2010).<\/p>\n<p>14.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Hayashi, Y.<em>, et al.<\/em> Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>34<\/strong>, 541-545 (2010).<\/p>\n<p>15.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Doo, A.R.<em>, et al.<\/em> Neuroprotective effects of an herbal medicine, Yi-Gan San on MPP+\/MPTP-induced cytotoxicity in vitro and in vivo. <em>Journal of ethnopharmacology<\/em> <strong>131<\/strong>, 433-442 (2010).<\/p>\n<p>16.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 de Caires, S. &amp; Steenkamp, V. Use of Yokukansan (TJ-54) in the treatment of neurological disorders: a review. <em>Phytother Res<\/em> <strong>24<\/strong>, 1265-1270 (2010).<\/p><!--CusAds0-->\n<p>17.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Uchida, N.<em>, et al.<\/em> Yokukansan inhibits social isolation-induced aggression and methamphetamine-induced hyperlocomotion in rodents. <em>Biological &amp; pharmaceutical bulletin<\/em> <strong>32<\/strong>, 372-375 (2009).<\/p>\n<p>18.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Tanaka, Y. &amp; Mizoguchi, K. Influence of aging on chondroitin sulfate proteoglycan expression and neural stem\/progenitor cells in rat brain and improving effects of a herbal medicine, yokukansan. <em>Neuroscience<\/em> <strong>164<\/strong>, 1224-1234 (2009).<\/p>\n<p>19.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Tabuchi, M.<em>, et al.<\/em> Ameliorative effects of yokukansan, a traditional Japanese medicine, on learning and non-cognitive disturbances in the Tg2576 mouse model of Alzheimer&#8217;s disease. <em>Journal of ethnopharmacology<\/em> <strong>122<\/strong>, 157-162 (2009).<\/p>\n<p>20.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Sekiguchi, K., Yamaguchi, T., Tabuchi, M., Ikarashi, Y. &amp; Kase, Y. Effects of yokukansan, a traditional Japanese medicine, on aggressiveness induced by intracerebroventricular injection of amyloid beta protein into mice. <em>Phytother Res<\/em> <strong>23<\/strong>, 1175-1181 (2009).<\/p>\n<p>21.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Monji, A.<em>, et al.<\/em> Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer&#8217;s disease. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>33<\/strong>, 308-311 (2009).<\/p>\n<p>22.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Mizukami, K.<em>, et al.<\/em> A randomized cross-over study of a traditional Japanese medicine (kampo), yokukansan, in the treatment of the behavioural and psychological symptoms of dementia. <em>The international journal of neuropsychopharmacology \/ official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)<\/em> <strong>12<\/strong>, 191-199 (2009).<\/p>\n<p>23.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Miyaoka, T.<em>, et al.<\/em> Charles Bonnet syndrome: successful treatment of visual hallucinations due to vision loss with Yi-gan san. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>33<\/strong>, 382-383 (2009).<\/p>\n<p>24.\u00a0\u00a0\u00a0\u00a0\u00a0 Miyaoka, T.<em>, et al.<\/em> Yi-gan san as adjunctive therapy for treatment-resistant schizophrenia: an open-label study. <em>Clinical neuropharmacology<\/em> <strong>32<\/strong>, 6-9 (2009).<\/p>\n<p>25.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kawakami, Z.<em>, et al.<\/em> Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells. <em>Neuroscience<\/em> <strong>159<\/strong>, 1397-1407 (2009).<\/p>\n<p>26.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kanno, H.<em>, et al.<\/em> Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats. <em>The Journal of pharmacy and pharmacology<\/em> <strong>61<\/strong>, 1249-1256 (2009).<\/p>\n<p>27.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Kamei, J., Miyata, S. &amp; Ohsawa, M. Involvement of the benzodiazepine system in the anxiolytic-like effect of Yokukansan (Yi-gan san). <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>33<\/strong>, 1431-1437 (2009).<\/p>\n<p>28.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Jiang, J.<em>, et al.<\/em> Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC\/Nga mice. <em>Journal of dermatological science<\/em> <strong>56<\/strong>, 37-42 (2009).<\/p>\n<p>29.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Izumi, M., Seki, T., Iwasaki, K. &amp; Sakamoto, K. Chinese herbal medicine Yi-Gan-San decreases the lipid accumulation in mouse 3T3-L1 adipocytes by modulating the activities of transcription factors SREBP-1c and FoxO1. <em>The Tohoku journal of experimental medicine<\/em> <strong>219<\/strong>, 53-62 (2009).<\/p>\n<p>30.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Ikarashi, Y.<em>, et al.<\/em> Effects of yokukansan, a traditional Japanese medicine, on memory disturbance and behavioral and psychological symptoms of dementia in thiamine-deficient rats. <em>Biological &amp; pharmaceutical bulletin<\/em> <strong>32<\/strong>, 1701-1709 (2009).<\/p>\n<p>31.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Tateno, M.<em>, et al.<\/em> Neuroprotective effects of Yi-Gan San against beta amyloid-induced cytotoxicity on rat cortical neurons. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>32<\/strong>, 1704-1707 (2008).<\/p>\n<p>32.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Takeda, A., Tamano, H., Itoh, H. &amp; Oku, N. Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan. <em>Neurochemistry international<\/em> <strong>53<\/strong>, 230-235 (2008).<\/p>\n<p>33.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Takeda, A., Itoh, H., Tamano, H., Yuzurihara, M. &amp; Oku, N. Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats. <em>Nutritional neuroscience<\/em> <strong>11<\/strong>, 41-46 (2008).<\/p>\n<p>34.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Shinno, H., Kamei, M., Nakamura, Y., Inami, Y. &amp; Horiguchi, J. Successful treatment with Yi-Gan San for rapid eye movement sleep behavior disorder. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>32<\/strong>, 1749-1751 (2008).<\/p>\n<p>35.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Shinno, H., Inami, Y., Inagaki, T., Nakamura, Y. &amp; Horiguchi, J. Effect of Yi-Gan San on psychiatric symptoms and sleep structure at patients with behavioral and psychological symptoms of dementia. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>32<\/strong>, 881-885 (2008).<\/p>\n<p>36.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Miyaoka, T.<em>, et al.<\/em> Yi-gan san for the treatment of neuroleptic-induced tardive dyskinesia: an open-label study. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>32<\/strong>, 761-764 (2008).<\/p>\n<p>37.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Miyaoka, T.<em>, et al.<\/em> Yi-gan san for the treatment of borderline personality disorder: an open-label study. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>32<\/strong>, 150-154 (2008).<\/p>\n<p>38.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Egashira, N.<em>, et al.<\/em> Repeated administration of Yokukansan inhibits DOI-induced head-twitch response and decreases expression of 5-hydroxytryptamine (5-HT)2A receptors in the prefrontal cortex. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>32<\/strong>, 1516-1520 (2008).<\/p>\n<p>39.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Shinno, H.<em>, et al.<\/em> Successful treatment with Yi-Gan San for psychosis and sleep disturbance in a patient with dementia with Lewy bodies. <em>Progress in neuro-psychopharmacology &amp; biological psychiatry<\/em> <strong>31<\/strong>, 1543-1545 (2007).<\/p>\n<p>40.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Iwasaki, K.<em>, et al.<\/em> A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. <em>The Journal of clinical psychiatry<\/em> <strong>66<\/strong>, 248-252 (2005).<\/p>\n<div class=\"1105701a103637095f64f2405c549ac8\" data-index=\"1\" style=\"float: none; margin:5px 0 5px 0; text-align:center;\">\n<script async src=\"https:\/\/pagead2.googlesyndication.com\/pagead\/js\/adsbygoogle.js\"><\/script>\r\n<ins class=\"adsbygoogle\"\r\n     style=\"display:block; text-align:center;\"\r\n     data-ad-layout=\"in-article\"\r\n     data-ad-format=\"fluid\"\r\n     data-ad-client=\"ca-pub-3630309833918220\"\r\n     data-ad-slot=\"2018820141\"><\/ins>\r\n<script>\r\n     (adsbygoogle = window.adsbygoogle || []).push({});\r\n<\/script>\n<\/div>\n<p>41.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Iwasaki, K.<em>, et al.<\/em> Effects of the traditional Chinese herbal medicine Yi-Gan San for cholinesterase inhibitor-resistant visual hallucinations and neuropsychiatric symptoms in patients with dementia with Lewy bodies. <em>The Journal of clinical psychiatry<\/em> <strong>66<\/strong>, 1612-1613 (2005).<\/p>\n<!--CusAds0-->\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Chinese: Yi Gan San English: Restrain the Liver Powder Source: Bao ying cuo yao (Synopsis of Caring for Infants) Pulse: bowstring, fine, soft Tongue: red, white coating Abdomen: fukuchokukinrenkyu, saijyoki Indications: This herbal formula has been used for patients with&nbsp;&hellip; <a href=\"https:\/\/kampo.ca\/herbs-formulas\/formulas\/yokukansan\/\">finish&nbsp;reading&nbsp;Yokukansan<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":27,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-325","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Yokukansan<\/title>\n<meta name=\"description\" content=\"Chinese: Yi Gan San English: Restrain the Liver Powder Source: Bao ying cuo yao (Synopsis of Caring for Infants) Pulse: bowstring, fine, soft Tongue: red,\" \/>\n<meta name=\"robots\" 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