Chinese: Fang Feng Tong Sheng San

English: Ledebouriella Powder that Sagely Unblocks

Source: Huang Di su wen xuan ming lun fang (Formulas from the Discussion Illuminating the Yellow Emperor’s Basic Questions)

Pulse: slippery, bowstring, rapid

Tongue: yellow, thick, greasy fur

Abdomen: medium to strong abdominal wall strength, fukuman

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Obesity
  • Heat constitution
  • Asthma
  • High blood pressure
  • Diabetes
  • Metabolic syndrome
  • Edema
  • High fever
  • Chills
  • Dizziness
  • Headache
  • Red and sore eyes
  • Nasal congestion with thick and sticky discharge
  • Sore throat
  • Dry mouth
  • A bitter taste in the mouth
  • Constipation
  • Dark urine

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

Herbs in This Formula

Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.


Basic and Clinical Research on Bofutsushosan – Updated on June 16, 2012

Ogawa H, Xu F, Uebaba K, et al. Antioxidative Potentiality of a Kampo Formulation Measured by an Ex Vivo Study. The Journal of Alternative and Complementary Medicine 2009; 15: 267-74.

Uebaba K, Xu F. Association between the SNP in sympathetic b3-adrenergic receptor gene and the efficacy of bofutsushosan. Nihon Toyo Igaku Zasshi (Kampo medicine) 2009; 54: S225.

Yamamoto N, Inada T. Bofu-tsusho-san effectively attenuates the weight gain observed after receiving olanzapine. Psychiatry and clinical neurosciences. 2008;62(6):747.

Yamakawa J, Ishigaki Y, Takano F, Takahashi T, Yoshida J, Moriya J, et al. The Kampo medicines Orengedokuto, Bofutsushosan and Boiogito have different activities to regulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles. Biological & pharmaceutical bulletin. 2008;31(11):2083-9.

Shimada T, Kudo T, Akase T, Aburada M. Preventive effects of Bofutsushosan on obesity and various metabolic disorders. Biological & pharmaceutical bulletin. 2008;31(7):1362-7.

Akagiri S, Naito Y, Ichikawa H, Mizushima K, Takagi T, Handa O, et al. Bofutsushosan, an Oriental Herbal Medicine, Attenuates the Weight Gain of White Adipose Tissue and the Increased Size of Adipocytes Associated with the Increase in Their Expression of Uncoupling Protein 1 in High-Fat Diet-Fed Male KK/Ta mice. Journal of clinical biochemistry and nutrition. 2008;42(2):158-66.

Hioki C. Efficacy of bofutsushosan in obese women with IGT. Pharma Medica 2007; 25: 43-8. I

Hioki C, Arai M. Bofutsushosan use for obesity with IGT: search for scientific basis and development of effective therapy with Kampo medicine. Journal of Traditional Medicines 2007; 24: 115-27.

Sakamoto S, Takeshita S, Sassa S, Suzuki S, Ishikawa Y, Kudo H. Effects of colestimide and/or Bofu-tsusho-san on plasma and liver lipids in mice fed a high-fat diet. In vivo. 2005;19(6):1029-33.

Ohno K, Chung HJ, Maruyama I, Tani T. Bofutsushosan, a traditional Chinese formulation, prevents intimal thickening and vascular smooth muscle cell proliferation induced by balloon endothelial denudation in rats. Biological & pharmaceutical bulletin. 2005;28(11):2162-5.

Suzuki S, Tanaka A, Arai T, Adachi M. [Case of interstitial pneumonitis induced by a Chinese herbal medicine, bofu-tsusho-san]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2004;42(8):777-81.

Hioki C, Yoshimoto K, Yoshida T. Efficacy of bofu-tsusho-san, an oriental herbal medicine, in obese Japanese women with impaired glucose tolerance. Clinical and experimental pharmacology & physiology. 2004;31(9):614-9.

Hioki C, Yoshimoto K, Yoshida T. Efficacy of Bofu-tsusho-san, an oriental herbal medicine, in obese Japanese women with impaired glucose tolerance. Clinical and Experimental Pharmacology and Physiology 2004; 31: 614-9.

Hioki C, Yoshimoto K, Yoshida T. Efficacy of bofu-tsusho-san in obese Japanese women with IGT. Rinsho Kampo Yakuri Kenkyukai Kaishi (Journal of the Society for Clinical Kampo Pharmacology), 2004; 100th Memorial Issue: 19-22.

Morimoto Y, Sakata M, Ohno A, Maegawa T, Tajima S. [Effects of Byakko-ka-ninjin-to, Bofu-tsusho-san and Gorei-san on blood glucose level, water intake and urine volume in KKAy mice]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2002;122(2):163-8.

Matsushima H, Takayanagi N, Ubukata M, Tokunaga D, Mori S, Sato N, et al. [A case of pneumonitis induced by Bofu-tsusho-san]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2002;40(12):955-9.

Morimoto Y, Sakata M, Ohno A, Maegawa T, Tajima S. [Effects of bofu-tsusho-san, a traditional Chinese medicine, on body fat accumulation in fructose-loaded rats]. Nihon yakurigaku zasshi Folia pharmacologica Japonica. 2001;117(1):77-86..

Yoshida T, Sakane N, Wakabayashi Y, Umekawa T, Kondo M. Thermogenic, anti-obesity effects of bofu-tsusho-san in MSG-obese mice. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 1995;19(10):717-22.