Chinese: Chai Hu Jia Long Gu Mu Li Tang

English: Bupleurum Plus Dragon Bone and Oyster Shell Decoction

Source: Shanghanlun (Treatise on Cold Damage Diseases)

Pulse: Bowstring, rapid

Tongue: Red body, yellow greasy coating

Abdomen: kyokyokuman, saijyoki, shinkahiko

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Irritability
  • Anxiety
  • Depression
  • insomnia
  • Palpitation
  • Neck and shoulder stiffness
  • Headache
  • Nervousness
  • anger
  • Constipation
  • Difficult urination
  • Epilepsy
  • Schizophrenia
  • Erectile dysfunction

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

Herbs in This Formula

Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.

Abdominal pattern (fukusho) of Saikokaryukotsuboreito (from Fukusho Kiran Yoku 1809)

Basic and Clinical Research on Saikokaryukotsuboreito (Chai Hu Jia Long Gu Mu Li Tang) – Updated on Mar 30, 2011

Hattori, T., et al. The fixed herbal drug composition “Saikokaryukotsuboreito” prevents bone loss with an association of serum IL-6 reductions in ovariectomized mice model. Phytomedicine 17, 170-177 (2010).

Mizoguchi, K., et al. Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced anxiety in rats: comparison with diazepam. Journal of natural medicines 63, 69-74 (2009).

Mizoguchi, K., et al. Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain. Pharmacology, biochemistry, and behavior 86, 55-61 (2007).

Tsujimura, A., et al. Clinical trial of treatment with saikokaryukotsuboreito for eugonadal patients with late-inset hypogonadism-related symptoms. Aging Male 11, 95-99 (2008).

Yoshie, F., et al. Protective effects of Saiko-ka-ryukotsu-borei-to (Chai-Hu-Jia-Long-Gu-Mu-Li-Tang) against atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Pharmacol Res 43, 481-488 (2001).

Fukushima M. Profiles of effects of traditional oriental herbal medicines on central nervous system in humans – assessment of Saiboku-to and Saiko-ka-ryukotsu-borei-to using EEG and pharmacokinetics of herbal medicine-derived ingredients as indices -. Seishin Shinkeigaku Zasshi (Psychiatria et Neurologia Japonica) 99: 355-69 (1997).

Hiramatsu M, Maehara I, Takahashi M, et al. Treatment experience with saikokaryukotsuboreito and hochuekkito in male infertility patients. Kampo Igaku (Kampo Medicine) 17: 246-8 (1993).

Saku K, Hirata K, Zhang B, et al. Effects of Chinese herbal drugs on serum lipids, lipoproteins and apolipoproteins in mild to moderate essential hypertensive patients. Journal of Human Hypertension 6: 393-5 (1992).