Ninjinyoeito

Ninjinyoeito

Chinese: Ren Shen Yang Ying Tang

English: Ginseng Decoction to Nourish the Nutritive Qi

Source: Taipinghuiminhejijufang (Prescriptions from the Great Peace Imperial Grace Pharmacy)

Pulse: sunken, fine, weak

Tongue: pale body

Abdomen: medium abdominal wall strength, shinkahiko

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Fatigue
  • Poor appetite
  • Anemia
  • Palpitations
  • Forgetfulness
  • Feverishness
  • Shortness of breath
  • Weight loss
  • Dry skin

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

Basic and Clinical Research on Ninjinyoeito – Updated on June 16, 2012

Tanaka K, Sawamura S. Therapeutic effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: Ninjin’yoeito) on nitric oxide-mediated lung injury in a mouse infected with murine cytomegalovirus. International immunopharmacology. 2006;6(4):678-85.

Motoo Y, Mouri H, Ohtsubo K, Yamaguchi Y, Watanabe H, Sawabu N. Herbal medicine Ninjinyoeito ameliorates ribavirin-induced anemia in chronic hepatitis C: a randomized controlled trial. World J Gastroenterol. 2005;11(26):4013-7.

Oda T, Ohnuki T, Kihara K, et al. A clinical study of a traditional Chinese herbal medicine, NINJIN-YOUEI TO in bone marrow suppression due to chemotherapy in gynecologic cancer. Yamagata Kenritsu Byoin Igaku Zasshi (The Yamagata Journal of Medicine) 2004; 38; 6-9 (in Japanese)

Kobayashi J, Seiwa C, Sakai T, Gotoh M, Komatsu Y, Yamamoto M, et al. Effect of a traditional Chinese herbal medicine, Ren-Shen-Yang-Rong-Tang (Japanese name: Ninjin-Youei-To), on oligodendrocyte precursor cells from aged-rat brain. International immunopharmacology. 2003;3(7):1027-39.

Aoe H, Sumida Y, Kawahara N, et al. Efficacy of an erythropoietin preparation and Kampo medicines in preoperative autologous blood donation in cancer patients. Jikoketsu Yuketsu (Journal of Japanese Society of Autologous Blood Transfusion) 1999; 12: 100-4 (in Japansese).

Nagao K, Nishimura R, Matsuda M, et al. Clinical evaluation of the combined effect of tegafur and hozai (traditional Chinese medicine). Toho Igaku (Eastern Medicine) 1998; 14: 63-71

Nakai S, Kawakita T, Himeno K, Nomoto K. Combined treatments with Ninjin-youei-to (Ren-shen-yang-rong-tang) plus a suboptimal dose of prednisolone on autoimmune nephritis in MRL/lpr mice. International journal of immunopharmacology. 1998;20(6):275-84.

Uchiyama Y, Nakajima S, Yoshida K, Mizukawa H, Haruki E. The effects of ninjinyoeito on cultured venous endothelial cells. The American journal of Chinese medicine. 1997;25(2):197-204.

Aoe H, Takada K, Kawahara N, et al. Effectiveness of erythropoietin and ninjin’yoeito in preoperative autologous blood donation. Jikoketsu Yuketsu (Journal of Japanese Society of Autologous Blood Transfusion) 1997; 10: 145-51 (in Japanese).

Nakai S, Kawakita T, Nagasawa H, Himeno K, Nomoto K. Thymus-dependent effects of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name; Ninjin-youei-to), in autoimmune MRI/MP-lpr/lpr mice. International journal of immunopharmacology. 1996;18(4):271-9.

Harigai E, Nakai S, Kawakita T, Nomoto K. Combined treatment with ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to) plus prednisolone on adjuvant-induced arthritis in Lewis rat. International journal of immunopharmacology. 1995;17(5):411-8.

Sugimachi K. A study of the usefulness of ninjin’yoeito in the postoperative adjuvant chemotherapy for gastric cancer. Rinsho to Kenkyu (Japanese Journal of Clinical and Experimental Medicine) 1995; 72: 454-8 (in Japanese).

Yanagihori A, Miyagi M, Hori M, et al. Efficacy of ninjin’yoeito for iron deficiency anemia. Rinsho to Kenkyu (Japanese Journal of Clinical and Experimental Medicine) 1995; 72: 2605-8 (in Japanese).

Okawa T, Hashimoto S, Sakamoto S, et al. Ninjin-Yoei-To in the treatment of leukopenia and symptoms associated with radiotherapy of malignant tumors. Gan no Rinsho (Japanese Journal of Cancer Clinics) 1995; 41: 41-51

Miyazaki Y, Yamada A, Saitou M. Effect of Ninjin-Youei-tou on xerostomia induced by oxybutynin hydrochloride. Shinyaku to Rinsho (Journal of New Remedies and Clinics) 1994; 43: 2613-7 (in Japanese).

Hasegawa K, Fukunishi H, Kiyoshige K, et al. Clinical usefulness of Kampo medicines (Ninjin-yoei-to, Juzen-taiho-to) for side effects in gynecologic cancer chemotherapy — Effects on reducing side effects by CDDP in CAP therapy—. Wakan Iyakugaku Gakkaishi (Journal of Traditional Medicines) 1994; 11: 181-7

Yamamoto T, Fujita H, Okada H, et al. Clinical evaluation of the effects of ninjin’yoeito on subjective and objective symptoms and bone-marrow function during chemotherapy or radiotherapy in female patients with genital cancer. Oncology & Chemotherapy 1994; 10: 126-34 (in Japanese).

Zhou NN, Nakai S, Kawakita T, Oka M, Nagasawa H, Himeno K, et al. Combined treatment of autoimmune MRL/MP-lpr/lpr mice with a herbal medicine, Ren-shen-yang-rong-tang (Japanese name: Ninjin-youei-to) plus suboptimal dosage of prednisolone. International journal of immunopharmacology. 1994;16(10):845-54.

Uchiyama Y, Nakajima S, Yoshida K, Mizukawa H, Haruki E. The effect of ninjinyoeito on human aorta endothelial cells. The American journal of Chinese medicine. 1994;22(3-4):293-9.

Fujii Y, Imamura M, Han M, Hashino S, Zhu X, Kobayashi H, et al. Recipient-mediated effect of a traditional Chinese herbal medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to), on hematopoietic recovery following lethal irradiation and syngeneic bone marrow transplantation. International journal of immunopharmacology. 1994;16(8):615-22.

Aoki T, Kojima T, Kameda N, Yoshijima S, Ono A, Kobayashi Y. [Anti-inflammatory effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to), on alveolar macrophages stimulated by RANTES or TNF-alpha]. Arerugi = [Allergy]. 1994;43(5):663-7.

Uchiyama Y, Nakajima S, Yoshida K, Mizukawa H, Haruki E. The effects of ninjinyoeito on human vascular endothelial cells. The American journal of Chinese medicine. 1993;21(3-4):279-89.

Nakai S, Kawakita T, Zhou NN, Matsuura K, Oka M, Nagasawa H, et al. Treatment effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to), on autoimmune MRL/MP-lpr/lpr mice. International journal of immunopharmacology. 1993;15(5):589-96.

Mizuno M, Yoshikawa H, Taketani Y, et al. Clinical effects of ninjin’yoeito on performance status (PS) and recovery of physical strength in patients following gynecologic cancer treatment — comparison with no-treatment controls. Sanka to Fujinka (Obstetrics and Gynecology1993; 60: 1533-45 (in Japanese).

Ohara T, Onda M, Futagawa S, et al. Clinical evaluation of the combined effect of Bu-Zhong-Yi-Qi-Tang (Japanese name, Hochu-ekki-to) or Ren-Shen-Yang-Rong-Tang (Japanese name, Ninjin-youei-to) and the anticancer drug tegafur. Yakuri to Chiryo (Japanese Phamacology & Therapeutics) 1993; 21: 4423-34 (in Japanese).

Araki Y, Tanaka T, Ogata Y, et al. Immunological evaluation of the efficacy of Kampo prescription for postoperative patients with colorectal cancer. Shinyaku to Rinsho (Journal of New Remedies and Clinic) 1992; 41: 1670-6 (in Japanese).

Yonekura K, Kawakita T, Saito Y, Suzuki A, Nomoto K. Augmentation of host resistance to Listeria monocytogenes infection by a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to). Immunopharmacology and immunotoxicology. 1992;14(1-2):165-90.

Uchiyama Y, Nakajima S, Ohno T, Goto M, Kan M, Haruki E. The effect of Ninjinyoeito on Werner’s syndrome skin fibroblasts. The American journal of Chinese medicine. 1992;20(3-4):295-305.

Miura S, Takimoto H, Yoshikai Y, Kumazawa Y, Yamada A, Nomoto K. Protective effect of ren-shen-yang-rong-tang (Ninjin-youei-to) in mice with drug-induced leukopenia against Pseudomonas aeruginosa infection. International journal of immunopharmacology. 1992;14(7):1249-57.

Okamura S, Shimoda K, Yu LX, Omori F, Niho Y. A traditional Chinese herbal medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-yoei-to) augments the production of granulocyte-macrophage colony-stimulating factor from human peripheral blood mononuclear cells in vitro. International journal of immunopharmacology. 1991;13(5):595-8.

Miura S, Kawamura I, Yamada A, Kawakita T, Kumazawa Y, Himeno K, et al. Effect of a traditional Chinese herbal medicine ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to) on hematopoietic stem cells in mice. International journal of immunopharmacology. 1989;11(7):771-80.