Chinese: Bai Wei Di Huang Wan (Jin Gui Shen Qi Wan)

English: Eight-Ingredient Pill with Rehmannia

Source: Jinguiyaolue (Essentials from the Golden Cabinet)

Pulse: Sunken, weak

Tongue: Pale, wet white fur

Abdomen: shofukufujin, shofukukokyu, midline lead

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Low back pain
  • Numbness in legs
  • Leg weakness
  • Cold feet
  • Aversion to cold
  • Fatigue
  • Erectile dysfunction
  • Nocturnal emission
  • Frequent urination
  • Difficult urination
  • Edema
  • Tinnitus
  • Dizziness

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

Herbs in This Formula

Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.


Abdominal pattern (fukusho) of Hachimijiogan (from Fukusho Kiran, 1800)

Basic and Clinical Research on Hachimijiogan – Updated on Mar. 30, 2011

Ikeda, R. & Mizoguchi, K. Hachimijiogan (Ba-Wei-Di-Huang-Wan), a herbal medicine, improves unbalance of calcium metabolism in aged rats. Journal of ethnopharmacology 124, 176-181 (2009).

Hijikata, Y., Miyamae, Y., Takatsu, H. & Sentoh, S. Two kampo medicines, jidabokuippo and hachimijiogan alleviate sprains, bruises and arthritis. Evid Based Complement Alternat Med 4, 463-467 (2007).

Oribe K, Nishida Y. Efficacy of hachimijiogan for discomfort after surgery for uterine prolapse. Gekkan Kampo Ryoho (Monthly Journal of Kampo Medicine and Herbs) 10: 282-8 (2006).

Wang XD, Yoshida K, Honda K, et al. Study of the immunoregulatory activity of the combination therapy with juzentaihoto and hachimijiogan in patients with disuse syndrome. Kampo Igaku (Kampo Medicine) 30: 65-7 (2006).

Ohno S. The effect of Kampo medicine on salivary secretion in Sjögren‘s syndrome. Kampo to Saishin-chiryo (Kampo & the Newest Therapy) 15: 134-40 (2006).

Yamada, K., Yagi, G. & Kanba, S. Effectiveness of herbal medicine (Rokumigan and Hachimijiogan) for fatigue or loss of energy in patients with partial remitted major depressive disorder. Psychiatry and clinical neurosciences 59, 610-612 (2005).

Maeshima S, Katayama Y. Spine and spinal cord diseases 1. Traditional Chinese medicines for the spinal disorders. Kampo to Saishin-Chiryo (Kampo & the Newest Therapy) 13: 232-6 (2004).

Iwasaki K, Kanbayashi S, Chimura Y, et al. A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine ―Ba wei di huang wan‖ in the treatment of dementia. Journal of the American Geriatrics Society 52: 1518-21 (2004).

Isobe H, Yamamoto K, Cyong JC. Effects of Hachimi-jio-gan (Ba-wei-di-huang-wan) on blood flow in the human central retinal artery. The American Journal of Chinese Medicine 31: 425-35 (2003).

Sekiguchi Y, Miyai K, Noguchi K, et al. Study of effects of anti-heat shock protein 60 antibody by Ba wei di huang wan and Qing xin lian zi yin (II). Wakan Iyakugaku Zasshi (Journal of Traditional Medicines) 15: 326-7 (1998).

Itoh T, Tanaka N, Shibahara N, et al. Effect of Hachimi- jio- gan on adrenal corticosteroids. Wakan Iyaku Gakkaishi (Journal of Medical and Pharmaceutical Society for WAKAN-YAKU) 15: 155-60 (1998).

Ishioka T. Comparative evaluation of Rokumigan and Hachimi-jiogan on senile pruritus. Therapeutic Research 16: 1497-504 (1995).

Hayashi Y, Saito E, Takahashi O. Usefulness of hachimijiogan for lumbar spinal stenosis. Geriatric Medicine 32: 585-91 (1994).

Fuse H, Sakamoto M, Iwasaki M, et al. Effect of Chorei-to and Hachimi-jio-gan on unidentified complatints on urinary tract. Hinyoki Geka (Japanese Journal of Urological Surgery) 8: 603-9 (1995).

Takamori S, Ando T. A study of the effect of hachimi-jio-gan on painful muscle cramps (komuragaeri). Nihon Toyo Igaku Zasshi (Japanese Journal of Oriental Medicine) 45: 151-7 (1994).

Hirokawa, S., Nose, M., Ishige, A., Amagaya, S. & Ogihara, Y. Effect of hachimijiogan, an oriental herbal medicinal mixture, on experimental amnesia in mice. Biological & pharmaceutical bulletin 17, 1182-1186 (1994).

Ishioka T, Aoi R. Comparative evaluation of hachimijiogan and ketotifen fumarate on senile pruritus. Shinyaku to Rinsho (Journal of New Remedies and Clinics) 41: 2603-8 (1992).

Usuki, S. & Ichikawa, Y. Effects of hachimijiogan on dopamine, serotonin and vasoactive intestinal peptide in plasma and hypothalamus in sulpiride-induced hyperprolactinemic rats. The American journal of Chinese medicine 19, 217-222 (1991).

Usuki, S. Effects of hachimijiogan, tokishakuyakusan, keishibukuryogan, ninjinto and unkeito on estrogen and progesterone secretion in preovulatory follicles incubated in vitro. The American journal of Chinese medicine 19, 65-71 (1991).

Otani, S., Usuki, S., Iwasaki, H., Inoue, S. & Yamashita, K. Successful treatment of a hyperprolactinemic infertile woman with a pituitary microadenoma using hachimijiogan. The American journal of Chinese medicine 19, 145-154 (1991).

Usuki, S. & Usuki, Y. Hachimijiogan treatment is effective in the management of infertile women with hyperprolactinemia or bromocriptine-resistant hyperprolactinemia. The American journal of Chinese medicine 17, 225-241 (1989).

Usuki, S., Kubota, S. & Usuki, Y. Treatment with hachimijiogan, a non-ergot Chinese herbal medicine, in two hyperprolactinemic infertile women. Acta obstetricia et gynecologica Scandinavica 68, 475-478 (1989).

Kaneko H, Nakanishi K, Murakami A, et al. Clinical evaluation of combination treatment of Hatimi-zio-gan and Red Ginseng Powder on unidentified clinical complaints – estimation of double blind comparative study in many hospitals. Therapeutic Research 10: 4951-65 (1989).

Tei M, Yamamoto T. Effects of hachimijiogan on mental activity and performance status in elderly. Gendai Iryogaku 5: 122-8 (1989).

Kaneko S, Akiyama T, Kurita T. Combined treatment of chronic prostatitis with sulfamethoxazole-trimethoprim. Hinyokika Kiyo (Acta Urologica Japonica) 34: 1091-5 (1988).

Ito K, Yamamoto H, Saibara T, et al. The usefulness of Kanebo Hachimijiogan in patients with hypertension or cerebrovascular disease (excluding acute phase symptoms) and their concomitant symptoms: a multicenter, double-blind, crossover study. Shindan to Chiryo (Diagnosis and Treatment) 76: 1096-114 (1988).

Usuki, S. Hachimijiogan and Tokishakuyakusan enhance deoxyribonucleic acid alpha-nucleotidyltransferase activity in relationship to DNA synthesis by ovarian follicles via a cyclic AMP system. The American journal of Chinese medicine 16, 37-46 (1988).

Usuki, S. Hachimijiogan produces testosterone in adult rat testes. The American journal of Chinese medicine 16, 93-105 (1988).

Usuki, S. Effects of hachimijiogan, tokishakuyakusan and keishibukuryogan on progesterone secretions by corpus luteum. The American journal of Chinese medicine 15, 109-115 (1987).

Usuki, S. Effects of hachimijiogan, tokishakuyakusan and keishibukuryogan on the corpus luteum function and weights of various organs in vivo. The American journal of Chinese medicine 15, 99-108 (1987).

Usuki, S. Hachimijiogan changes serum hormonal circumstance and improves spermatogenesis in oligozoospermic men. The American journal of Chinese medicine 14, 37-45 (1986).

Usuki, S. Effects of hachimijiogan, tokishakuyakusan and keishibukuryogan on estrogen and progesterone secretions by rat preovulatory follicles. The American journal of Chinese medicine 14, 161-170 (1986).

Haranaka, R., et al. Pharmacological action of hachimijiogan (Ba-wei-wan) on the metabolism of aged subjects. The American journal of Chinese medicine 14, 59-67 (1986).

Yamamoto T, Tei M. Effects of Kampo medicine on immunocompetence in the elderly (III) – effects on the activity of the alternative complement pathway. Wakan Iyaku Gakkaishi (Journal of Medical and Pharmaceutical Society for WAKAN-YAKU) 3: 270-1 (1986).

Yoshida, H., et al. The effects of Ba-wei-wan (hachimijiogan) on plasma levels of high density lipoprotein-cholesterol and lipoperoxide in aged individuals. The American journal of Chinese medicine 13, 71-76 (1985).