Chinese: Si Ni San

English: Frigid Extremities Powder

Source: Shanghanlun (Treatise on Cold Damage Diseases)

Pulse: bowstring

Tongue: red body, yellow coating

Abdomen:kyokyokuman, fukuchokukinrenkyu

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Cold extremities
  • Irritability
  • Poor appetite
  • Abdominal pain
  • Nervousness

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

Herbs in This Formula


Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.


Abdominal pattern (fukusho) of Shigyakusan (from Fukusho Kiran, 1800)

Basic and Clinical Research on Shigyakusan – Updated on Mar. 30, 2011

Watanabe H. A study of peptic ulcer maintenance therapy combined with Kampo medicines. Kampo Igaku (Kampo Medicine) 1995; 19: 18-21.

Sakurada T, Ikeda K, Takasaka T, et al. Clinical effectiveness of Kampo medicine for chronic rhinitis and sinusitis. Jibiinkoka Rinsho (Practica otologica) 1992; 85: 1341-6.

Inoue M. Kampo therapy for mastitis – shigyakusan. Kampo Igaku (Kampo Medicine) 1990; 14: 132-6.