Chinese: Huang Lian Jie Du Tang
English: Coptis Decoction to Reliebve Toxicity
Pulse: Rapid, forceful
Tongue: Red body, yellow fur
Indications: This herbal formula has been used for patients with following health conditions and symptoms:
- High fever
- Dry mouth and throat
- Dark urine
There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.
Herbs in This Formula
- Obaku (Phellodendri Cortex), 3g
- Ogon (Scutellariae Radix) 3g
- Oren (Coptidis Rhizoma) 2g
- Sanshishi (Gardeniae Fructus) 2g
Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.
Basic and Clinical Research on Orengedokuto (Huang Lian Jie Du Tang) – Updated on Mar. 30, 2011
Zeng, H., et al. Huang-Lian-Jie-Du-Tang exerts anti-inflammatory effects in rats through inhibition of nitric oxide production and eicosanoid biosynthesis via the lipoxygenase pathway. The Journal of pharmacy and pharmacology 61, 1699-1707 (2009).
Park, S., Hong, S.M., Ahn, I.S., Kim, Y.J. & Lee, J.B. Huang-Lian-Jie-Du-Tang supplemented with Schisandra chinensis Baill. and Polygonatum odoratum Druce improved glucose tolerance by potentiating insulinotropic actions in islets in 90% pancreatectomized diabetic rats. Bioscience, biotechnology, and biochemistry 73, 2384-2392 (2009).
Li, X., et al. Huang-Lian-Jie-Du-Tang inhibits myocardial remodeling in a rat model of metabolic syndrome. Journal of ethnopharmacology 119, 259-265 (2008).
Hsu, Y.L., et al. Huang-lian-jie-du-tang, a traditional Chinese medicine prescription, induces cell-cycle arrest and apoptosis in human liver cancer cells in vitro and in vivo. Journal of gastroenterology and hepatology 23, e290-299 (2008).
Zhang, D.M., et al. In-vivo and in-vitro studies on the effect of Huang-Lian-Jie-Du-Tang on nimodipine transport across rat blood-brain barrier. The Journal of pharmacy and pharmacology 59, 1733-1738 (2007).
Lu, T., et al. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. Journal of ethnopharmacology 110, 412-418 (2007).
Arakawa K, Saruta T, Abe K, et al. Improvement of accessory symptoms of hypertension by TSUMURA Orengedokuto Extract, a four herbal drugs containing Kampo-Medicine Granules for ethical use: a double-blind, placebo-controlled study. Phytomedicine 13: 1-10 (2006).
Ma, Z., et al. Baicalein, a component of Scutellaria radix from Huang-Lian-Jie-Du-Tang (HLJDT), leads to suppression of proliferation and induction of apoptosis in human myeloma cells. Blood 105, 3312-3318 (2005).
Arakawa K, Saruta T, Abe K, et al. Double-blind placebo-controlled trial of TSUMURA Orengedokuto (TJ-15) for the treatment of accessory symptoms of hypertension. Rinsho to Kenkyu (Japanese Journal of Clinical and Experimental Study) 80: 354-72 (2003)
Ikeda N, Hayasaka S, Nagaki Y, et al. Effects of traditional Sino-Japanese herbal medicines on aqueous flare elevation after small-incision cataract surgery. Journal of Ocular Pharmacology and Therapeutics 17: 59-65 (2001).
Akiyama Y, Ohno S, Asaoka T, et al. The combination therapy with sarpogrelate hydrochloride and Kampo medicine (oren-gedoku-to or toki-shakuyaku-san) for Raynaud’s phenomenon. Japanese Journal of Oriental Medicine 51: 1101-8 (2001).
Xu, J., et al. Protective effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice. Journal of ethnopharmacology 73, 405-413 (2000).
Yamada K. 3. Kampo treatment in psychiatry. In: Role of Kampo medicines on the stress-related disorders in a modern society. Nihon Toyo Igaku Zasshi (Kampo Medicine) 49: 774-80 (1999).
Yamada K, Kanba S, Ohnishi K, et al. Clinical effectiveness of Oren-Gedoku-To for sleep disorder associated with acute schizophrenia and other psychotic disorders. Nihon Toyo Igaku Zasshi (Japanese Journal of Oriental Medicine) 47: 827-31 (1997).
Narumi J, Kohsaka S, Miyazawa S, et al. Evaluation of the Kampo monotreatment for hypertensive patients using ambulatory blood pressure monitoring. Kampo Shinryo 15: 34-5 (1996).
Narumi J, Kohsaka S, Miyazawa S, et al. Evaluation of the Kampo monotreatment for hypertensive patients using ambulatory blood pressure monitor. Wakan Iyakugaku Zasshi (Journal of Traditional Medicines) 11: 282-3 (1994).
Ohkuma M. Treatment of pruritus by Chinese drugs with external application and oral antihistamine. Wakan Iyakugaku Zasshi (Journal of Traditional Medicines) 11: 302-3 (1994).
Ohkuma M. Treatment of pruritus by Chinese drugs. Wakan Iyaku Gakkaishi (Journal of Medical and Pharmaceutical Society for WAKAN-YAKU) 10: 126-30 (1993).
Ohkuma M. Treatment of acne by Chinese drugs and external application. Wakan Iyaku Gakkaishi (Journal of Medical and Pharmaceutical Society for WAKAN-YAKU) 10: 131-4 (1993).
Ohkuma M. Treatment of acne by Chinese drugs and external application – comparison with oral antibiotics -. Nihon Toyo Igaku Zasshi (Japanese Journal of Oriental Medicine) 44: 173-7 (1993).
Araki G. Effects of TSUMURA Orengedokuto for sequelae of cerebrovascular accident*. Geriatric Medicine; 29: 1587-99 (1991)
Otomo E, Togi H, Kogure K, et al. Clinical usefulness of TSUMURA Orengedokuto for the treatment of cerebrovascular disease: a well-controlled study comparing TSUMURA Orengedokuto versus Ca hopantenate, using sealed envelopes for allocation. Geriatric Medicine 29: 121-51 (1991).
Ohkawara A, Furuya K, Kurisu Y, et al. Experience with orengedokuto (TJ-15) and goshajinkigan (TJ-107) for the treatment of senile pruritus. Nishinihon Hifuka (The Nishinihon Journal of Dermatology) 53: 1234-41 (1991).
Ito E, Takahashi A, Kuzuya F. Clinical effectiveness of TSUMURA Orengedokuto in the treatment of cerebral infarction. Geriatric Medicine 29: 303-13 (1991).
Kaneko H, Nakanishi K, Murakami A, et al. Clinical evaluation of the effect of Ohrengedoku-Toh and Ohrengedoku-Toh – Red Ginseng mixture on chronic cardiovascular disorders in middle and aged patients. The Ginseng Review 12: 89-93 (1991).
Shichido T, Arichi S. Preventive effects of Kampo medicine (orengedokuto) on hangover – a double-blind randomized pilot study. Igaku no Ayumi (Journal of Clinical and Experimental Medicine) 145: 789-95 (1998).