Chinese: Da Chai Hu Tang

English: Major Bupleurum Decoction

Source: Shanghanlun (Treatise on Cold Damage Diseases)

Pulse: bowstring-rapid, sunken-bowstring, bowstring-forceful

Tongue: red body, dry-yellow fur, white-yellow fur

Abdomen: shinkahiko, kyokyokuman

Indications: This herbal formula has been used for patients with following health conditions and symptoms:

  • Irritability
  • Restlessness
  • Nausea
  • Vomiting
  • Burning diarrhea or constipation
  • Asthma
  • Shoulder stiffness
  • Gastritis
  • Hypertension
  • Gall stone

There are many other health conditions that may respond well to this herbal formula, in particular patients exhibiting indicative traditional diagnostic signs and symptoms.

Abdominal pattern (fukusho) of Daisaikoto (from Fukusho Kiran, 1800)

Abdominal pattern (fukusho) of Daisaikoto (from Fukusho Kiran Yoku 1809)


Herbs in This Formula


Note: Suggested dosages of each herb in Kampo formulas are often smaller than those of Traditional Chinese Medicine (TCM). Individual dosages of herbs may be adjusted depending on each patient’s condition, constitutional patterns, quality of the herbs, and other factors involved.
Basic and Clinical Research on Daisaikoto (Da Chai Hu Tang ) – Updated on Mar. 30, 2011

Yamano S, Sawai F, Hashimoto T, et al. Comparative effects between Dai-Saiko-to and elastase on lipid metabolism and cerebral circulation in patients with hyperlipidemia. Kampo to Saishin-chiryo (Kampo & The Newest Therapy) 4: 309-13 (1995)

Sasaki J, Matsunaga A, Kusuda M, et al. Efficacy of daisaikoto and chotosan in patients with essential hypertension. Rinsho to Kenkyu (Japanese Journal of Clinical and Experimental Medicine) 70: 1965-75 (1993)

Muramatsu N, Okayasu M. Clinical study on hyperlipidemia at bezafibrate and Da-chai-hu-tang (Dai-saiko-to) for the combination therapy. Shigaku (Odontology) 81: 94-9 (1993)

Takashima T, Ohmori K, Higuchi N, et al. Combination therapy with probucol and daisaikoto (a Kampo medicine) – Effects of daisaikoto on HDL metabolism.  Domyaku Koka (The Journal of Japan Atherosclerosis Society) 21: 47-52 (1993)

Saku K, Hirata K, Zhang B, et al. Effects of Chinese herbal drugs on serum lipids, lipoproteins and apolipoproteins in mild to moderate essential hypertensive patients. Journal of Human Hypertension 6: 393-5 (1992)

Sasaki J, Matsunaga A, Handa K, et al. Effect of daisaikoto on hyperlipidemia – comparison with clinofibrate. Rinsho to Kenkyu (Japanese Journal of Clinical and Experimental Medicine) 68: 3861-71 (1991)

Murakami T, Oku J, Kimura Y, et al. The effect of Oriental medicine (dai-sai-ko-to) with probucol on lipoprotein metabolism in non-insulin dependent diabetics with hypercholesterolemia. Domyaku Koka (The Journal of Japan Atherosclerosis Society) 19: 839-46 (1991)